基因检测指导个体化用药.ppt

Irinotecan SN-38 (羧酸)酯酶 UGT1A1 SN-38G SN-38G UGT1A6 UGT1A9 UGT1A1基因检测及伊立替康 Group Prevalence Risk of Toxicity *28/*28 10% 50% *1/*28 40% 12.5% *1/*1 50% 0% Based on data from Innocenti et al (2004) UGT1A1基因检测及伊立替康 All Patients with Same Diagnosis (10% risk) PGx pro high risk (50%): treat with alternative drug or dose PGx Pro moderate risk (12.5%): treat with alternative drug or dose PGx Pro low risk (0%): treat with conventional dose UGT1A1基因检测及伊立替康 UGT1A1A检测及伊立替康 TPMT检测与嘌呤类 DPYD、MTHFR检测与5-FU类 CYP 2C9、VKORC1检测与华法林 GST、XRCC1、ERCC1检测与铂类 APOE检测与他汀类 嘌呤类抗癌药物：主要有6-巯基嘌呤(6-MP)、6-硫鸟嘌