老年男性2型糖尿病患者甲状腺功能及甲状腺自身抗体水平研究.docVIP

GIP Chinese General Practice 2011年3月第14卷第3B期 ·843 · · 论 著 · 老年男性2型糖尿病患者甲状腺功能及甲状腺自身抗体 水平研究 陈陵霞，苗懿德，刘杰，宝辉，郏蓉，褚琳，魏雅楠 【摘要】 目的 探讨老年男性2型糖尿病患者甲状腺功能、甲状腺自身抗体的变化及相关影响因素。方法 选 取老年男性2型糖尿病患者97例 (T2DM 组)及非糖尿病患者155例(对照组)。采用化学发光法分别测定两组的甲 状腺功能〔血清三碘甲状腺原氨酸 (T?)、 甲状腺素 (T?)、 游离三碘甲状腺原氨酸 (FT?)、 游离甲状腺素 (FT?)、 促甲状腺素 (TSH)〕 及甲状腺自身抗体〔抗甲状腺过氧化物酶抗体 (aTPO)、 抗甲状腺球蛋白抗体 (aTG)〕 水平。 同时收集体质指数 (BMI)、 空腹血糖、糖化血红蛋白 (HbA,。)、 血脂等相关临床资料。对比分析两组患者上述指标间 的差异及影响因素。 结果 T2DM 组患者T? 水平较对照组显著降低〔(7.58±1.48)μg/dl 与(8.01±1.63)μg/dl〕 aTG 较对照组显著升高〔(77±130) U/ml 与(44±60) U/ml〕,差异均有统计学意义 (P0.05)。 相关分析结果显 示：T4 水平与FT? 、FT? 、T3 水平及BMI 呈正相关，与TSH 呈负相关 (P0.01);aTG 与 aTPO 呈正相关 (P0.01)。 结论 老年男性2型糖尿病患者甲状腺功能及甲状腺自身抗体已有改变，表现为 T? 水平下降， aTG 水平升高。 BMI 对 T4有影响， aTG 与aTPO 存在相关性。 【关键词】 糖尿病，2型；老年人；男人；甲状腺功能；甲状腺自身抗体 【中图分类号】 R587.1 【文献标识码】 A 【文章编号】1007-9572(2011)03-0843-02 Cha nges of Thyroid Function and Thyroid Autoantibody in Elderly Male Patients with Type 2 Diabetes CHEN Ling - xia,MAO Yi-de,LIU Jie, et al. Department of Geriatrics,Pehing University Peoples Hospital,Beijing 100044,China 【Abstract】 Objective To investigate the changes of thyroid function and thyroid autoantibody in male patients with type 2 diabetes and its influence factor. Methods 97 male patients with type 2 diabetes(T2DM group)and 155 non diabetes patients(control group) were included. SerumT?,T,FT3,FT?,TSH,aTG and aTPO were tested by chemoluminescence method. Clinical data including BMI, fast glucose, HbA,c, Cholesterol,Triglyceride were collected simultaneously. Differ- ences between the two groups and influence factors were analyzed statistically. Results T4 was significantly lower in T2DM group compared with control group〔(7.58±1.48)μg/dl vs(8.01±1.63)μg/dl 〕(P0.05); aTG was significantly higher in T2DM group compared with control group〔(76.9±129.8)U/ml vs(44.2±60.2)U/ml 〕(P0.05). Analysis showed that there was a positive correlation between T4 and FT.,FT?,T; and BMI, and there was also a positive correlation between aTG and aTPO(P0.