被动吸烟对女性2型糖尿病患者尿清蛋白排泄率的影响.docVIP

·2528 · · 论 著 · 被动吸烟对女性2型糖尿病患者尿清蛋白排泄率的影响 潘清蓉，张伟，徐援 【摘要】 目的 探讨被动吸烟对不吸烟的女性2型糖尿病患者尿清蛋白排泄率 (UAE) 的影响。方法 对2009 年6月—2011年4月在我院住院的521例不吸烟的女性2型糖尿病患者进行被动吸烟的调查，比较被动吸烟暴露者和 非被动吸烟暴露者的基本资料、胰岛功能、血脂水平、炎症标志物〔C 反应蛋白 (CRP)、 纤维蛋白原、白细胞计数〕 和8 hUAE。 被动吸烟暴露的定义是与吸烟的家人或同事接触至少5年。结果 不吸烟的女性2型糖尿病患者中，294 例(56.4%)为被动吸烟暴露者(暴露组),227例(43.6%)为非被动吸烟暴露者(非暴露组)。暴露组患者受教育 年限显著短于非暴露组，差异有统计学意义 (P0.05), 血 CRP、 纤维蛋白原水平和8 h UAE 均显著高于非暴露组， 差异有统计学意义 (P0.05), 而血高密度脂蛋白胆固醇 (HDL-C) 水平则显著低于非暴露组，差异有统计学意义 (P0.05)。 多元逐步回归分析显示，糖尿病病程、收缩压、 CRP、 胰岛素抵抗指数 (HOMA-IR) 和被动吸烟累积量 是不吸烟的女性2型糖尿病患者8 h UAE 的独立影响因子。结论 被动吸烟会增加女性2型糖尿病患者的 UAE、 血 CRP 及纤维蛋白原水平，并加重血脂代谢亲乱。 【关键词】 烟草烟污染；糖尿病，2型；尿清蛋白排泄率；危险因素 【中图分类号】 R587.1 【文献标识码】 A 【文章编号】1007-9572(2012)08-2528-03 In fluence of Passive Smoking on Urine Albumin Excretion in Women Patients with Type 2 Diabetes Mellitus PAN Qing -rong,ZHANG Wei,XU Yuan. Department of Endocrinology,Beijing Chaoyang Hospital,Capital Medical University,Beijing 100020,China 【Abstract】 Objective To investigate the influence of passive smoking on urine albumin exeretion(UAE) in non - smoking women patients with type 2 diabetes mellitus(T2DM). Methods Survey of passive smoking was conducted in 521 non - smoking women patients with T2DM hospitalized in our department from June 2009 to April 2011. Basic information,pancreat- ic function, blood lipid, inflammation marker(CRP, fibrinogen and leukocyte count)and 8 h UAE were compared between passive smoking exposure group and passive smoking non - exposure group. Passive smoking was defined as exposure to smoking family members or collengues for at least five years. Results Among the non - smoking women patients with T2DM, 294 cases (56.4%)were exposed to passive smoking(exposure group)and 227(43.6%)cases were not exposed to passive smoking (non-exposure group). Years of education,CRP, fibrinogen and 8 h UAE of the exposure group were significantly higher than those of the non - exposure group(P0.05), while the level of HDL-C was signi