吡格列酮对2型糖尿病患者氧化应激的影响.docVIP

·888 · · 短 篇 论 著 · 吡格列酮对2型糖尿病患者氧化应激的影响 殷松楼，周冬梅，奚珏，庄玮，殷寒秋 【摘要】 目的 探讨吡格列酮对2型糖尿病患者氧化应激的影响。方法 收集于本院就诊的2型糖尿病患者 130例，随机分成对照组和吡格列酮组，每组65例。对照组给予门冬胰岛素30和二甲双胍控制血糖；吡格列酮组使用 门冬胰岛素30、二甲双胍和吡格列酮(15 mg/d) 降糖治疗，均治疗3个月。治疗前后检测并比较两组患者血清氧化 应激指标：超氧化物歧化酶 (SOD)、 谷胱甘肽过氧化物酶 (GSH-Px)、 丙二醛 (MDA)。 结果 治疗后吡格列酮组 患者血清SOD、GSH-Px 活性〔(54±18) U/ml 和(82±18) U/ml〕 较治疗前〔(39±16) U/ml 和(71±22) U/ ml〕 显著升高， MDA 水平〔(2.6±1.7) nmol/ml〕 较治疗前〔(3.8±2.3) nmol/ml〕 显著降低，差异有统计学意义 (P0.05), 且治疗后吡格列酮组上述3种指标与对照组〔(42±18) U/ml、(73±19)U/ml 和(3.5±1.8) nmol/ ml 〕比较，差异有统计学意义 (P0.01)。 结论 吡格列酮能提高2型糖尿病患者血清SOD 和 GSH-Px 活性，降低 MDA 水平，而且吡格列酮的这种作用不依赖于降糖作用。 【关键词】 糖尿病，2型；噻唑烷二酮类；吡格列酮；超氧化物歧化酶；谷胱甘肽过氧化物酶；丙二醛 【中图分类号】 R587.1 【文献标识码】 B 【文章编号】1007-9572(2010)03-0888-03 Effect of Pioglitazone on Oxidative Stress in T2DM Patients YTN Song-lou,ZHOU Dong-mei, XI Jue, et al. Affiliated Hospital of Xuzhou Medical College,Xuzhou 221002,China 【Abstract 】 Objective To investigate the effects of pioglitazone on oxidative stress in T2DM. Methods One hun- dred thirty T2DM patients were randomized into groups control and Pioglitazone, 65 in each. Control group were given insulin as- part 30 and metformin to control blood glucose; Pioglitazone group insulin aspart 30, metformin and Pioglitazone (15 mg/d) for hypoglycemic treatment. The treatments lasted 3 months. Serum oxidative stress indicators such as superoxide dismutase(SOD), glutathione peroxidase(GSH-Px)and melondialdehyde(MDA) were determined before and after treatment. Results In Pio- glitazone group, activities of SOD and GSH-Px were significantly higher after treatment (54±18 U/ml,82±18 U/ml,respec- tively) than before(39±16 U/ml,71±22 U/ml,respectively),MDA level lower(2.6±1.7nmol/ml,3.8±2.3 nmol/ml, respectively),the difference was significant(P0.05). Pioglitazone group was different from control in the above 3 indicators (42±18 U/ml,73±19 U/ml,3.5±1.8 nmol/ml,respectively)after treatment,the difference was si