补肾化浊胶囊制剂治疗糖尿病肾病98例临床观察.docVIP

·438 · · 中 医 · 中 西 医 结 合 · 补肾化浊胶囊制剂治疗糖尿病肾病98例临床观察 王淑花，赵丽，邢文广，唐淑芬，裘松雅，韩文生 【摘要】 目的 观察补肾化浊胶囊对糖尿病肾病的治疗作用。方法 将162例糖尿病肾病患者随机分为两组， 两组均给予控制饮食、控制血糖、控制血压等常规治疗，对照组给予洛汀新口服，治疗组给予补肾化浊胶囊口服制剂， 连用3个月，比较两组治疗前后的中医症候积分、尿蛋白、血脂、血清一氧化氮 (NO)、 血清C- 反应蛋白 (CRP) 的变化。 结果 两组治疗后中医症状积分变化比较，差异有统计学意义 (P0.05); 治疗后，两组尿白蛋白排泄率、 24h尿蛋白定量均减少，差异无统计学意义 (P0.05); 治疗组血清胆固醇 (TC)、 三酰甘油 (TG) 及 CRP 水平降 低，NO 水平升高，与治疗前比较均有统计学意义 (P0.05), 两组治疗后的TC、TG、CRP、NO 水平比较有统计学 意义 (P0.05); 两组临床疗效比较差异无统计学意义 (P0.05)。 结论 补肾化浊胶囊可改善糖尿病肾病的临床症 状，通过降低尿蛋白、抑制肾脏内炎症反应、升高血清NO、 改善脂代谢异常实现对肾脏的保护作用。 【关键词】 糖尿病肾病；补肾化浊胶囊； C- 反应蛋白；肾功能 【中图分类号】 R587.24 【文献标识码】 A 【文章编号】1007-9572(2010)02-0438-03 Treatment of Diabetic Nephropathy with Bushen Huazhuo Capsule: A clinical report of 98 cases WANG Shu -hua, ZHAO Li,XING Wen-guang, et al. Cangzhou Central Haspital,Cangzhou 061000,China 【Abstract】 Objective To observe the clinical efficacy of Bushen Huazhuo Capsule for the patients with diabetic ne- phropathy. Methods Totally 162 patients with diabetic nephropathy were divided as control group and trial group. All the pa- tients were given conventional treatments of controlling diet, blood sugar and blood pressure. The patients in the control group were orally given Lotesin, while the patients in the trial group were given Bushen Huazhuo Capsule for 3 months. Then a compari- son was conducted between the two groups on the Chinese medicine symptom integral, and the changes of urine protein, lipids, serum nitric oxide(NO),and serum C- reactive protein(CRP). Results After treatment,the difference in Chinese medi- cine symptom integral between the two groups was statistically significant(P0.05).But there was no significant difference be- tween the two groups in excretion rate of urine protein and 24h urine protein(P0.05). The levels of total cholesterol(TC), triglyceride(TG)and CRP decreased, and the NO level increased(P0.05). The levels of TC,TG,CRP,and NO after treatment between the two g