077.正交试验法优化静配中心注射用哌拉西林钠他唑巴坦钠调配方案.pdf

交试验法优静配中心注射用拉西林钠他唑巴坦钠调配方案

摘要目的利用交试验优静配中心注射用拉西林钠他唑巴坦钠

(Piper且化illinSo北ium且n北T且zob且化t且mSo北iumforInje化tion)的调配方案

方法选定溶媒类型溶媒体积和压力个因素，个因素确定两个水，即溶

媒类型0.9%氯钠注射液和灭菌注射用水，溶媒体积5ml和8ml，压力常

压和负压，进因素两水的交试验，考察各个因素对调配注射用拉西林

钠他唑巴坦钠溶解时间的影结果影注射用拉西林钠他唑巴坦钠溶解时

间的次因素溶媒体积最大，压力次之，溶媒类型最小，在调配注射用拉西

林钠他唑巴坦钠过程中，使用8ml灭菌注射用水并保持负压状，溶解时间最短

结论选用宜的调配方案，可使注射用拉西林钠他唑巴坦钠溶解时间缩短，

提高静配中心工作效率

关键词静配中心注射用拉西林钠他唑巴坦钠交试验调配溶解

时间

OptimizingtheAllocationSchemeofPiperacillinSodiumandTazobactam

Sodium(81)forInjectioninPharmacyIntravenousAdmixtureServiceby

∶

OrthogonalExperiment

QILei,GAOJie,LVChang-liang,LVFei-fei(CentralHospitalOfZiBo,ShandongZibo

255000,China)

Abstract:ObjectiveTheallocationschemeofpiperacillinsodiumandtazobactam

sodium(8∶1)forinjectioninpharmacyintravenousadmixtureservicewillbe

optimizedbyorthogonalexperiment.MethodsTherearethreefactors,menstruum

types,menstruumvolumesandpressures.Everyfactorensurestwolevels.Menstruum

typesare0.9percentsodiumchlorideinjectionansterilewaterforinjection,

menstruumvolumesare5mland8mlandpressuresareordinarypressureand

negativepressure.Thethree-factorandtwo-levelorthogonalexperimentisconducted

toexaminetheinfluencesofeveryfactorsontheresolvingtimeofpiperacillinsodium

andtazobactamsodium(8∶1)forinjection.ResultsThesequenceofprimaryand

secondaryfactorswhichinfluenceonresolvingtimeofpiperacillinsodiumand

tazobactamsodium(8∶1)forinjectionfromstrongtoweakaremenstruumvolumes,

1

pressuresandmenstruumtypes.Intheprocessofallocatingpiperacillinsodiumand

tazobactamsodium(8∶1)forinjection,whenusing8mlsterilewaterforinjection

andkeepingnegativepressure,theresolvingtimeistheshortest.ConclusionUsing

o