BRCA1-IN-2-Standard-生命科学试剂-MCE.pdfVIP

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BRCA1-IN-2(Standard)

Cat.No.:HY-100862R

CASNo.:1622262-55-8

分⼦式:C₂₆H₃₃N₄O₇P

分⼦量:544.54

作⽤靶点:PARP;ReferenceStandards

作⽤通路:CellCycle/DNADamage;Epigenetics;Others

储存⽅式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

⽣物活性BRCA1-IN-2(Standard)是BRCA1-IN-2(HY-100862)的分析标准品。本产品⽤于研究及分析应⽤。BRCA1-IN-

2(compound15)是具有细胞渗透性的BRCA1蛋⽩-蛋⽩相互作⽤(PPI)的抑制剂，IC50值0.31μM，Kd值为

0.3μM，BRCA1-IN-2通过阻断BRCA1(BRCT)2/蛋⽩质相互作⽤⽽具有抗肿

IC50TargetIC50:0.31μM(BRCA1)[1]

Kd:0.3μM(BRCA1)[1]

REFERENCES

[1].NaZ,etal.Protein-ProteinInteractionInhibitorsofBRCA1DiscoveredUsingSmallMoleculeMicroarrays.MethodsMolBiol.

2017;1518:139-156.

McePdfHeight

Caution:Producthasnotbeenfullyvalidatedformedicalapplications.

Forresearchuseonly.

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