MAO-B-IN-51-生命科学试剂-MCE.pdfVIP

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MAO-B-IN-51

Cat.No.:HY-103477

CASNo.:947540-06-9

分⼦式:C₁₅H₁₆F₃N₃O₂S

分⼦量:359.37

作⽤靶点:MonoamineOxidase

作⽤通路:NeuronalSignaling

储存⽅式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

⽣物活性MAO-B-IN-51(Compound8f)是⼀种选择性、可穿透⾎脑屏障的⼝服活性MAO-B抑制剂，其IC50值为48.9

nM(MDS)。MAO-B-IN-51可增强长期记忆[1]。

IC50TargetMAO-B

48.9nM(IC50)

REFERENCES

[1].KaplanAP,etal.Identificationof5-(1-Methyl-5-(trifluoromethyl)-1H-pyrazol-3-yl)thiophene-2-CarboxamidesasNovelandSelective

MonoamineOxidaseBInhibitorsUsedtoImproveMemoryandCognition.ACSChemNeurosci.2017Dec20;8(12):2746-2758.

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