MAP4K4-IN-7-生命科学试剂-MCE.pdfVIP

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MAP4K4-IN-7

Cat.No.:HY-W402208

CASNo.:1499162-60-5

分⼦式:C₁₂H₈FN₅

分⼦量:241.22

作⽤靶点:MAP4K

作⽤通路:MAPK/ERKPathway

储存⽅式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

⽣物活性MAP4K4-IN-7(Compound8)是⼀种MAP4K4抑制剂。MAP4K4-IN-7对TNIK、MAP4K4和MINK1表现出中

等抑制活性，其pIC50值分别为6.8、6.8和6.7。MAP4K4-IN-7可⽤于癌症和神经系统疾病的研究，如精神分

裂症[1]。

IC50TargetMAP4K4TNIKMINK1/MAP4K6

6.8(pIC50)6.8(pIC50)6.7(pIC50)

REFERENCES

[1].ReadJ,etal.ToolinhibitorsandassaystointerrogatethebiologyoftheTRAF2andNCKinteractingkinase.BioorgMedChemLett.

2019Aug1;29(15):1962-1967.

McePdfHeight

Caution:Producthasnotbeenfullyvalidatedformedicalapplications.

Forresearchuseonly.

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