MAI-400-生命科学试剂-MCE.pdfVIP

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MAI-400

Cat.No.:HY-126016

CASNo.:2250328-65-3

分⼦式:C₄₁H₅₆N₈O₁₅

分⼦量:900.93

作⽤靶点:APC

作⽤通路:CellCycle/DNADamage

储存⽅式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

⽣物活性MAI-400是⼀种APC-Asef相互作⽤抑制剂(Kd=12nM，IC50=250nM）。MAI-400可⽤于结直肠癌的研究

。

IC50TargetKd=12nM,IC50=250nM(APC-Asefinteraction)[1]

REFERENCES

[1].YangX,etal.RationalDesignandStructureValidationofaNovelPeptideInhibitoroftheAdenomatous-Polyposis-Coli(APC)-Rho-

Guanine-Nucleotide-Exchange-Factor-4(Asef)Interaction.JMedChem.2018Sep13;61(17):8017-8028.

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Caution:Producthasnotbeenfullyvalidatedformedicalapplications.

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1/1MasterofBioactiveMolecules—您⾝边的抑制剂⼤师