MANT-cGMP-生命科学试剂-MCE.pdfVIP

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MANT-cGMP

Cat.No.:HY-137750

CASNo.:83707-15-7

分⼦式:C₁₈H₁₉N₆O₈P

分⼦量:478.35

作⽤靶点:AdenylateCyclase

作⽤通路:GPCR/GProtein

储存⽅式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

⽣物活性MANT-cGMP是⼀种核糖取代的核苷酸，是腺苷酸环化酶(AC)抑制剂，其Ki值为100μM，pKi值为4。

MANT-cGMP可⽤于研究⼼⼒衰竭、癌症和神经系统疾病。

REFERENCES

[1].WangJL,etal.Aconformationaltransitionintheadenylylcyclasecatalyticsiteyieldsdifferentbindingmodesforribosyl-modifiedand

unmodifiednucleotideinhibitors.BioorgMedChem.2007Apr15;15(8):2993-3002.

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