MB725-生命科学试剂-MCE.pdfVIP

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MB725

Cat.No.:HY-119408

CASNo.:2230058-99-6

分⼦式:C₁₈H₂₁IN₄O₂S

分⼦量:484.36

作⽤靶点:MDM-2/p53;Bcl-2Family

作⽤通路:Apoptosis

储存⽅式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

⽣物活性MB725是MB710(HY-120373)的⼄酰胺类似物。MB725可提⾼多种p53靶基因的mRNA⽔平，特别是

PUMA、p21、MDM2、NOXA和BAX。MB725对p53-Y220C突变型癌细胞具有选择性抗癌活性[1]。

IC50TargetBax

REFERENCES

[1].BaudMGJ,etal.Aminobenzothiazolederivativesstabilizethethermolabilep53cancermutantY220Candshowanticanceractivityin

p53-Y220Ccelllines.EurJMedChem.2018May25;152:101-114.

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Caution:Producthasnotbeenfullyvalidatedformedicalapplications.

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