MBM-55-Standard-生命科学试剂-MCE.pdfVIP

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Inhibitors•ScreeningLibraries•Proteins

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MBM-55(Standard)

Cat.No.:HY-101029R

CASNo.:2083622-09-5

分⼦式:C₂₈H₂₇FN₆O₂

分⼦量:498.55

作⽤靶点:NEKs;Apoptosis;ReferenceStandards

作⽤通路:CellCycle/DNADamage;Apoptosis;Others

储存⽅式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

⽣物活性MBM-55(Standard)是MBM-55(HY-101029)的分析标准品。本产品⽤于研究及分析应⽤。MBM-55是有效的

NIMA-relatedkinase2(Nek2)抑制剂，IC50值为1nM，是其他激酶选择性的20倍甚⾄更⾼，除了RSK1

(IC50=5.4nM)和DYRK1a(IC50=6.5nM)。MBM-55通过诱导细胞

IC50TargetIC50:1nM(Nek2),5.4nM(RSK1),6.5nM(DYRK1a),57nM(CHK1),91nM(GSK-3β),20nM(ABL),370

nM(CDK2),441nM(CDK4),608nM(AKT1),5300nM(AuroraA)[1]

REFERENCES

[1].XiJB,etal.Structure-baseddesignandsynthesisofimidazo[1,2-a]pyridinederivativesasnovelandpotentNek2inhibitorswithinvitro

andinvivoantitumoractivities.EurJMedChem.2017Jan27;126:1083-1106.

McePdfHeight

Caution:Producthasnotbeenfullyvalidatedformedicalapplications.