NVX-207-Standard-生命科学试剂-MCE.pdfVIP

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NVX-207(Standard)

Cat.No.:HY-101597R

CASNo.:745020-66-0

分⼦式:C₃₆H₅₉NO₆

分⼦量:601.86

作⽤靶点:ReferenceStandards;Apoptosis

作⽤通路:Others;Apoptosis

储存⽅式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

⽣物活性NVX-207(Standard)是NVX-207(HY-101597)的分析标准品。本产品⽤于研究及分析应⽤。NVX-207是⼀种

Betulinicacid衍⽣的抗癌化合物，对不同的⼈和⽝细胞株具有抗肿瘤活性(平均IC50=3.5μM)。NVX-207诱

导的细胞凋亡(apoptosis)与caspases-9，-3，-7和PARP的裂解与内在凋亡途径的激活有关。

REFERENCES

[1].WillmannM,etal.CharacterizationofNVX-207,anovelbetulinicacid-derivedanti-cancercompound.EurJClinInvest.2009;39(5):384-

394.

[2].BacheM,etal.BetulinicacidderivativesNVX-207andB10fortreatmentofglioblastoma--aninvitrostudyofcytotoxicityand

radiosensitization.IntJMolSci.2014Oct30;15(11):19777-90.

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