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(rel)-Nutlincarboxylicacid

Cat.No.:HY-128837A

CASNo.:2760669-71-2

分⼦式:C₃₂H₃₂Cl₂N₄O₆

分⼦量:639.53

作⽤靶点:LigandsforE3Ligase

作⽤通路:PROTAC

储存⽅式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

⽣物活性(rel)-Nutlincarboxylicacid是⼀种基于Nutlin3的MDM2配体。(rel)-Nutlincarboxylicacid可通过linker与

靶蛋⽩配体连接，形成PROTAC分⼦。

IC50TargetMDM2

REFERENCES

[1].LiG,etal.APARP1PROTACasanovelstrategyagainstPARPinhibitorresistanceviapromotionofferroptosisinp53-positivebreast

cancer.BiochemPharmacol.2022Dec;206:115329.

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Caution:Producthasnotbeenfullyvalidatedformedicalapplications.

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