rel-PRT062607-rel-P505-15-生命科学试剂-MCE.pdfVIP

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Inhibitors•ScreeningLibraries•Proteins

www.MedChemE

(rel)-PRT062607

Cat.No.:HY-15322A

CASNo.:1194954-52-3

Synonyms:(rel)-P505-15;(rel)-PRT-2607;(rel)-BIIB-057

分⼦式:C₁₉H₂₃N₉O

分⼦量:393.45

作⽤靶点:Syk;DrugIsomer

作⽤通路:ProteinTyrosineKinase/RTK;Others

储存⽅式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

⽣物活性(rel)-PRT062607是PRT062607(HY-15322)的相对构型。PRT062607是Syk激酶⾼效选择性抑制剂，IC50值

为1-2nM，对Fgr、Lyn、FAK、Pyk2和Zap70抑制⼒弱80倍以上。

REFERENCES

[1].CoffeyG,etal.Specificinhibitionofspleentyrosinekinasesuppressesleukocyteimmunefunctionandinflammationinanimalmodelsof

rheumatoidarthritis.JPharmacolExpTher.2012Feb;340(2):350-9.

[2].SpurgeonSE,etal.TheselectiveSYKinhibitorP505-15(PRT062607)inhibitsBcellsignalingandfunctioninvitroandinvivoand

augmentstheactivityoffludarabineinchroniclymphocyticleukemia.JPharmacolExpTher.2013Feb;344(2):378-87.

[3].HoellenriegelJ,etal.Selective,novelspleentyrosinekinase(Syk)inhibitorssuppresschroniclymphocyticleukemiaB-cellactivation

and