REV7-REV3L-IN-1-Standard-生命科学试剂-MCE.pdfVIP

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REV7/REV3L-IN-1(Standard)

Cat.No.:HY-100468R

CASNo.:1979192-13-6

分⼦式:C₁₉H₂₁N₃O₃S

分⼦量:371.45

作⽤靶点:DNA/RNASynthesis;ReferenceStandards

作⽤通路:CellCycle/DNADamage;Others

储存⽅式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

⽣物活性REV7/REV3L-IN-1(Standard)是REV7/REV3L-IN-1(HY-100468)的分析标准品。本产品⽤于研究及分析应⽤。

REV7/REV3L-IN-1是⼀种REV7/REV3L相互作⽤抑制剂，IC50值为78μM，在核磁共振分析中，其直接与

REV7结合，并抑制在启动⼦和报告⼦区域之间含有链间交联(ICL)的报告载体的再活化[1]。

IC50TargetIC50:78μM(REV7/REV3Linteraction)[1]

REFERENCES

[1].ActisML,etal.Identificationofthefirstsmall-moleculeinhibitoroftheREV7DNArepairproteininteraction.BioorgMedChem.2016

Sep15;24(18):4339-4346.

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Caution:Producthasnotbeenfullyvalidatedformedicalapplications.

Forresearchuseonly.

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