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Remetinostat(Standard)

Cat.No.:HY-100365R

CASNo.:946150-57-8

分⼦式:C₁₆H₂₁NO₆

分⼦量:323.34

作⽤靶点:HDAC;ReferenceStandards

作⽤通路:CellCycle/DNADamage;Epigenetics;Others

储存⽅式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

⽣物活性Remetinostat(Standard)是Remetinostat(HY-100365)的分析标准品。本产品⽤于研究及分析应⽤。

Remetinostat(SHP-141)是⼀种基于羟肟酸的组蛋⽩去⼄酰化酶(HDAC)抑制剂。Remetinostat缓解

Imiquimod(HY-B0180)诱发的银屑病⽪炎。Remetinostat⽤于⽪肤T细胞淋巴瘤研究[1][2]。

IC50TargetHDAC[1].

REFERENCES

[1].YijunDeng,etal.ProcessDevelopmentoftheSoftHistoneDeacetylateEnzymeInhibitorSHP-141:AcylationofMethylParabenand

SuberylHydroxamicAcidFormation.Org.ProcessRes.Dev.2016,20,10,1812-1820.

[2].JinL,etal.TopicalhistonedeacetylaseinhibitorremetinostatimprovesIMQ-inducedpsoriaticdermatitisviasuppressingdendriticcell

maturationandkeratinocytedifferentiationandinflammation.EurJPharmacol.2024Nov15;983:177011.

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