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SF2523(Standard)

Cat.No.:HY-101146R

CASNo.:1174428-47-7

分⼦式:C₁₉H₁₇NO₅S

分⼦量:371.41

作⽤靶点:PI3K;ReferenceStandards;EpigeneticReaderDomain;DNA-

PK

作⽤通路:PI3K/Akt/mTOR;Others;Epigenetics;CellCycle/DNA

Damage

储存⽅式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

⽣物活性SF2523(Standard)是SF2523(HY-101146)的分析标准品。本产品⽤于研究及分析应⽤。SF2523是⼀种有效

的选择性PI3K抑制剂，抑制PI3Kα，PI3Kγ，DNA-PK，BRD4和mTOR，IC50分别为34nM，158nM，9

nM，241nM和280nM。

IC50TargetIC50:34nM(PI3Kα),158nM(PI3Kγ),9nM(DNA-PK),241nM(BRD4),280nM(mTOR)[1]

REFERENCES

[1].CarlinoL,etal.DualKinase-BromodomainInhibitorsinAnticancerDrugDiscovery:AStructuralandPharmacologicalPerspective.JMed

Chem.2016Oct27;59(20):9305-9320.

[2].AndrewsFH,etal.Dual-activityPI3K-BRD4inhibitorfortheorthogonalinhibitionofMYCtoblocktumorgrowthandmetastasis.Proc

NatlAcadSciUSA.2017Feb14;114(7):E1072-E1080.

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