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SH-273

Cat.No.:HY-177908

CASNo.:3084159-97-4

分⼦式:C₄₃H₃₆N₁₀O₈S

分⼦量:852.87

作⽤靶点:STING;PI3K

作⽤通路:Immunology/Inflammation;PI3K/Akt/mTOR

储存⽅式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

⽣物活性SH-273是⼀种双靶点化合物。SH-273具有双重功能，既能刺激STING功能（EC50100nM），⼜能抑制PI3K

γ(IC50:7nM)。SH-273可⽤于胰腺癌的研究[1]。

IC50TargetEC50:100nM(STING);IC50:7nM(PI3Kγ)

REFERENCES

[1].LiC,etal.OvercomingBregulatorycellinducedSTINGresistancebydualfunctionalalbuminnanomedicinetoprolongsurvivalof

pancreaticcancer.CancerResearch,2024,84(6_Supplement):6534-6534.

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