抗高血压药英文版专家讲座.pptxVIP

hypertensionMeanarterialbloodpressureishigherthanthenormalrange,inthecaseofnottakingbloodpressuredrugs：

Systolicbloodpressure≥18.7kPa(140mmHg)and（or）

Diastolicbloodpressure≥12.0kPa(90mmHg)Dividedintoprimaryhypertension（90%~95%）Andsecondaryhypertension抗高血压药英文版专家讲座第1页

complicationsHeartfailureCoronaryheartdisease(CHD)CerebrovascularaccidentRenalfailure抗高血压药英文版专家讲座第2页

AntihypertensivedrugsReasonableapplicationofantihypertensivedrugsControlofbloodpressureDelaytheformationanddevelopmentofatherosclerosisReducethecomplicationssuchasbrain,heartandkidneyReducethemortalityrate,prolonglife抗高血压药英文版专家讲座第3页

Bloodpressure-Thefactorsinfluencingbloodpressure：Cardiacoutput:heartrate,myocardialcontractionforce,changeofbloodvolume,etc.;Peripheralresistance:thelengthofthebloodvesselsandbloodviscosity,bloodvessels,radius,etc.-Nerve-fluidsystemonbloodpressureregulation。抗高血压药英文版专家讲座第4页

maincentreganglionVascularsmoothmuscleclonidine?-methyldopaEplerenonemecamylamineReserpineguanethidine?propranolol?1?prazosin?1?labetalolhydralazinesodiumnitroprussidenifedipineminoxidil1.Nervousregulation:thesympatheticnervoussystemPeripheralneurotransmitterreleaseThepostsynapticmembranereceptor抗高血压药英文版专家讲座第5页

Second,humoralregulation:renin–angiotensinaldosteronesystemKidneyadjacentballBesidethemachine?-RblockersreninAngiotensinoriginalangiotensinⅠinvertaseACEIangiotensinⅡSmallarterycontractionlosartanAldosteronesecretionWatersodiumretentiondiuretic(thiazides)抗高血压药英文版专家讲座第6页

ClassificationDiureticThesympatheticnervousdepressants(1)centralbloodpressuremedication(2)theganglionblock(3)noradrenalinecannerveendingsblock(4)theadrenalinereceptorblockersAffecttherenin-angiotensinsystemmedicineAgleamofantihypertensives:diuretic,calciumantagonistmedicine,betareceptorblockersandACEI抗高血压药英文版专家讲座第7页

DiureticOnthebasisof(aline)blood