抗癫痫药专题知识培训.pptxVIP

抗癫痫药专题知识培训抗癫痫药专题知识培训第1页

Definitionsinepilepsy:Epilepsycomprisesrecurrentepisodesofabnormalcerebralneuronaldischarge.Theresultingseizuresareusuallyclinicallyobviousandvaryinpatternaccordingtowhichpartsofthebrainareaffected.Epilepsycanbecausedbymanyneurologicaldiseases,includinginfection,trauma,infarctionandneoplasia.Heredityhasanimportantrole(especiallyintheidiopathicgeneralisedepilepsies).抗癫痫药专题知识培训第2页

NormalbraincellAbnormalhigh-frequencydischargeFocusDrugactionInhibitdischargeStabilizemembrane,inhibitthediffusionofdischarge(primary)抗癫痫药专题知识培训第3页

CommonseizuretypesofEpilepsy:Generalisedseizures.Absence(petitmal).Tonic/clonic(grandmal).Partialseizures.Simplepartialseizures.Complexpartialseizures(temporallobeepilepsy).抗癫痫药专题知识培训第4页

Generalisedseizures:Absence(petitmal):Theseseizureshaveabruptonsetandcessation,withimpairedconsciousness,butwithnormalpostureoftenretained.TheEEGshowsatypical‘spikeandwave’pattern.Tonic/clonic(grandmal):Consciousnessisimpairedandthepatientusuallyfallstothefloor.Aphaseofmusclecontraction(‘tonic’)isfollowedbyirregularmuscleclonusandthenbysleep.Injurymayoccur.抗癫痫药专题知识培训第5页

Partialseizures:Simplepartialseizures:featuresdependonthepartofthebrainaffected,resultfromdischargeintheprecentralgyrus.Consciousnessisunimpaired.Complexpartialseizures(temporallobeepilepsy):Consciousnessisimpairedwithcomplex,oftenrepetitive,action.抗癫痫药专题知识培训第6页

TheEEGinseizureofEpilepsy3HzParadoxicaldischargeSpikewave抗癫痫药专题知识培训第7页

EpilepsyPathogenesis:Theneuroninbrainlesiondepolarizestogethersuddenly,andthenproducthigh-frequency,out-breakdischarge.Thedischargecandiffusetosurroundingnormaltissue→extensiveexcitation→thebrainfunctiontransientaberration.抗癫痫药专题知识培训第8页

NormalbraincellAbnormalhigh-frequencydischargeFocusDrugactionInhibitdischargeStabiliz