药物缓释载体负载药物方法研究.pdfVIP

第25卷第3期 生命科学 Vol. 25, No. 3 2013年3月 Chinese Bulletin of Life Sciences Mar., 2013 文章编号：1004-0374(2013)03-0329-05 ∙ 技术与应用∙ 药物缓释载体负载药物方法的研究 袁君杰，谢幼专* (上海市骨科内植物重点实验室，上海交通大学医学院附属第九人民医院骨科，上海200011) 摘　要：药物经过合适的载体负载后，不仅能够达到缓释的目的，还能够改变药物的给药方式，以此减少 给药次数，降低药物不良反应，提高药物的生物利用度。如何将药物负载到载体材料上并达到较高的载药 量和包封率是决定缓释效果的关键因素之一。根据载体材料结构和药物特性选择合适的负载方法可获得具 有良好缓释效果的药物缓释系统。本文回顾了药物缓释载体负载药物的几种常用方法：喷雾干燥法、乳化 溶剂挥发法、自乳化溶剂扩散法、相分离法、溶液吸附法、直接填充法和化学结合等。现就药物缓释载体 材料与药物的物理结合和化学结合两种方法作一综述。 关键词：药物缓释 ；负载 ；物理结合；化学结合 中图分类号：R318.08 文献标志码：A Study on methods of drug loading into delivery carriers YUAN Jun-Jie, XIE You-Zhuan* (Shanghai Key Laboratory of Orthopaedic Implant, Department of Orthopaedic Surgery, Shanghai Ninth People’s Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200011, China) Abstract: Loading of drugs into appropriate delivery carrier material can not only improve their sustained and controlled release property but also alter route of administration, which prolongs dosing interval, reduces adverse reaction and improves biological availability. How to load drug into drug delivery carrier material and reach high drug loading capacity and encapsulation rate is critical for determining efficacy of drug sustained release. Selecting appropriate drug loading method based on the structure of delivery carrier material and properties of drugs can obtain a drug delivery system with good sustained release efficacy. This article presents a general summary of several common loading methods of drugs into delivery material, including spray drying method, emulsion solvent ev