阿托伐他汀对老年大鼠心肌缺血再灌注损伤及多器官功能的保护作用.pdfVIP

·322 · 南方医科大学学报（J South Med Univ ） 2012;32(3) 基础研究 阿托伐他汀对老年大鼠心肌缺血再灌注损伤及多器官功能的保 护作用 张今尧，王浩，叶平 解放军总医院南楼心血管内二科，北京100853 摘要：目的观察阿托伐他汀对老年大鼠心肌缺血再灌注过程中心脏的影响，并进一步关注此过程中肝、肾功能的变化。方法 10月龄Wistar 大鼠饲养至20 月龄，阿托伐他汀灌胃至24 月龄，分为大剂量他汀组、小剂量他汀组、老年对照组，并设立青年对照 组。采用结扎冠状动脉方法建立心肌缺血再灌注模型，纪录缺血再灌注过程中大鼠死亡率、血流动力学变化、心肌梗塞面积变 化，及肝肾功能指标。结果 与老年对照组相比，青年对照组及大剂量他汀组在缺血再灌注过程中死亡率明显降低（P0.05）、血 流动力学紊乱减少、心梗面积减小（P0.05）；青年对照组及大剂量他汀组在缺血再灌注后，肝肾功能无明显恶化，小剂量他汀组 肝脏功能显著恶化（P0.05），老年对照组肝肾功能均出现显著恶化（P0.05）。结论 阿托伐他汀对老年大鼠心肌缺血再灌注过 程中的心、肝、肾多器官产生保护作用。 关键词：老年；阿托伐他汀；缺血再灌注；肝肾功能 中图分类号：R54 文献标志码：A 文章编号：1673-4254（2012）03-0322-07 DOI: CNKI:44-1627/R0919.005 /kcms/detail/44.1627.R0919.005.html Protective effect of atrovastatin against myocardial ischemia-reperfusion injury and on liver and kidney functions in aged rats ZHANG Jinyao, WANG Hao, YE Ping Second Department of Geriatric Cardiology, General Hospital of PLA, Beijing 100853, China Abstract: Objuctive To observe the effect of atorvastatin against myocardial ischemia-reperfusion injury and its protective effect on liver and kidney functions. Methods Ten-month-old Wistar rats were fed to the age of 20 months, and atorvastatin statins gavage was administered till 24 months. The rats were divided into high-dose statin group, small-dose statin group, aged control group and young control group. The myocardial ischemia-reperfusion model was established by ligating the coronary artery. The mortality, hemodynamic changes, infarct size and liver and kidney functions of the rats were recorded or measured. Results Compared with the aged control group, the young control group and high-dose statin group showed significantly lower mortality rate, reduced hemodynamic abnormalities, and smaller myocardial infarct size following my