蠕虫免疫调控与免疫相关疾病.pdfVIP

中国科技论文在线 蠕虫免疫调控与免疫相关疾病# 杨维平，田芳，胡雪莉* （扬州大学医学院病原生物学与免疫学教研室，江苏 扬州 225001） 5 摘要：蠕虫在免疫应答中是重要的调控者。许多研究发现蠕虫感染后虫源性分子诱导免疫细 胞形成免疫调节网络，介导免疫抑制，从而抑制过敏和自身免疫性炎性疾病。在诱导免疫抑 制网络过程中，寄生虫可以通过诱导免疫调节细胞活化和产生细胞因子发挥抑制效应，从而 影响其他免疫相关疾病。然而，蠕虫感染与免疫相关疾病之间的调节机制尚无明确的结论。 一些蠕虫感染可以保护和控制过敏性疾病，而另一些蠕虫却加剧疾病的免疫病理损害。 10 关键词：蠕虫；免疫相关疾病；免疫调节；免疫调节细胞 中图分类号：R383 Immune related diseases and helminth immunoregulation YANG Weiping, TIAN Fang, HU Xueli 15 (Department of Pathogen Biology and Immunology, Medical College of Yangzhou University, JiangSu YangZhou 225001) Abstract: Helminths are important regulators in immune response. Many studies showed that helminth-derived molecules can induce immunoregulatory cells to form immune network-mediated immune, thereby inhibiting allergic and autoimmune inflammatory diseases. In 20 the process of inducing immunosuppresive network, parasites can induce immune cell activation and produce cytokine. And parasites play an inhibitory effect to affect other immune related diseases. However, the association between helminths infections and immune related diseases does not always have an unequivocal outcome. While some helminths infections protect against allergic diseases, other helminth can exacerbate this immunopathology. 25 Keywords: helminths; immune related diseases; immune regulation; immunoregulatory cells 0 引言 寄生蠕虫通常以免疫逃避机制在感染宿主体内建立慢性感染。蠕虫感染后立即产生虫源 性分子并促进先天性免疫和适应性免疫反应的过程和发展。蠕虫感染可以诱导树突状细胞 30 （DCs ）、调节性T 细胞（Treg ）、调节性B 细胞（Breg ）和巨噬细胞（AAMs ）