进出口化妆品中的喹诺酮药物测定 液相色谱-串联质谱法 英文意见稿.docVIP

Foreword The standard was drafted by GB/T 1.1-2009. This standard was proposed by and is under the charge of the Certification and Accreditation Administration of the People’s Republic of China. The standard was drafted by Shenzhen Entry-Exit Inspection and Quarantine Bureau of the People’s Republic of China, Shenzhen Institute of Inspection and Quarantine. The main drafters of this standard are Lin Li, Zhang Yi, Tu Xiaoke,Xie Liqi,Yue Zhengfeng, Kang Haining, Luo Yao This standard is promulgated for the first time. Determination of Quinolones Residues in Cosmetics for Import and Export —— LC-MS/MS method 1 Scope This standard applies to 25 quinolone drugs residues in cosmetics by LC-MS/MS method. This standard applies to water class, paste, cream and emulsion cosmetic quantitative determination of quinolone drugs and those found in. 2 Normative references Following provisions of this standard became the standard terms of reference. Any date reference, subsequent amendments (does not include the contents of the corrigenda) or revision shall not apply to this standard, however, encouraged the parties to reach agreement in accordance with this practice to study the possibility of using the latest versions of these files. An undated reference file applies to the latest version of this standard. GB/T 6682 water for analytical laboratory use specification and test methods. 3 principle Acidic acetonitrile extracted sample residues of quinolone drugs, hexane skim, after concentration, constant volume, LC-MS/MS detection and confirmation, outside the statutory amount. 4 Reagents and material Unless otherwise specified, all reagents used should be of analytical grade. “Water” is deionized. 4.1 Acetonitrile: HPLC grade 4.2 Methanol: HPLC grade 4.3 Formic acid: HPLC grade. 4.4 Acetate: HPLC grade 4.5 n-Hexane: HPLC grade 4.6 Sodium chloride: content ≥ 99.5%. 4.7 Acetonitrile formic acid solution: precise lessons of 2 mL acid (4.3), using a constant volume acetoni