运脾固表法防治小儿反复呼吸道感染的肠道微生态机制研究.DOCVIP

临床医学论文-运脾固表法防治小儿反复呼吸道感染的肠道微生态机制研究 ??????????????? 作者：许双虹 陈晓刚 胡小英 刘华 赖东兰 李宜瑞 徐金燕 【摘要】? ［目的］探讨运脾固表法对反复呼吸道感染儿的肠道微生态的影响。［方法］选择1～12岁肺脾气虚型反复呼吸道感染患儿60例，随机分为治疗组30例，对照组30例，治疗组口服运脾固表的中药复感宁方，对照组口服培菲康散（双歧三联活菌），疗程12周，比较两组治疗后双歧杆菌和肠杆菌菌群变化及B/E值，并与正常组对照。［结果］治疗后治疗组粪便标本中的双歧杆菌含量高于对照组（P0.05），B/E值也高于对照组（P0.05），而肠杆菌含量两组比较差异无显著意义（P0.05）。治疗后两组粪便标本中的双歧杆菌含量及B/E值都仍然低于正常组（P0.05），治疗组肠杆菌与正常组比较差异无显著意义（P0.05），对照组则仍高于正常组（P0.05）。［结论］运脾固表法能提高反复呼吸道感染儿肠道中双歧杆菌的数量及B/E值，降低肠杆菌含量，改善肠道微生态结构。 【关键词】? 呼吸道感染；肺脾气虚；运脾固表；肠道微生态；小儿 　　Abstract：［Objective］ To explore the effect of the method of activating spleen to solidify superficial on intestinal microecology of children recurrent respiratory tract infection.［Method］ Select 60 cases aged 1～12 of Qi deficiency type of lung and spleen in recurrent respiratory tract infection,randomly divide them into treatment group 30 cases and control 30;the treatment one takes TCM Fugangning formula orally for activating spleen to solidify superficial;the other takes orally BIFICO,for 12 w;compare their Bifidobacteria(B) and Escherichia coli(E) changes and B/E value after treatment,compare it to the control one’s.［Result］ After treatment,in the dejecta samples,the B content was higher than that in control one（P0.05）,so was B/E;while E had no marked difference between them（P0.05）;the B and E content and B/E were lower than normal group（P0.05）;there’s no marked difference compared with normal group on B（P0.05）， while control group was more than the normal group（P0.05）.［Conclusion］ Activating spleen to solidify superficial can improve B content and B/E in the intestine of children recurrent respiratory tract infection,reduce E content and improve intestinal microecological structure. 　　Key words: respiratory tract infection;Qi deficiency of lung and spleen;activate spleen to solidify superfacial;intestinal microecology;children 　　反复呼吸道感染（Recurrent Respiratory Tract Infection，RRTI）是指根据不同的年龄段，呼吸道感染每年发病在一定次数以上。其临床特点为反复发作的上、下呼吸道感染，部分患儿上感后可迅速发展为支气管炎或肺炎，少数则诱发哮喘。我们应用运脾固表法防治小儿反复呼吸道感染取得较好的临床疗效