不对称15二芳基14戊二烯3酮类化合物合成及生物活性研究.pdf

目 录 摘 要·················································································································1 Abstract Abstract AAbbssttrraacctt·············································································································· 2 前 言·················································································································3 第一章 文献综述···································································································4 1.1 1,4- -3- 1.1 1,4- -3- 11..11 11,,44--戊二烯--33--酮类似物结构改变和生物活性方面的研究进展································4 1.1.1 对形成羰基的酮的结构改变和生物活性方面的研究进展4 1.1.2 对芳环类型及芳环取代基的改变和生物活性方面的研究进展·····························9 1.2 1.2 11..22 姜黄素类似物结构改变和生物活性方面的研究进展··········································12 1.2.1 对形成羰基的酮的结构改变和生物活性方面的研究进展12 1.2.2 对芳环类型及芳环取代基的改变和生物活性方面的研究进展15 1.2.3 对亚甲基的结构改变和生物活性方面的研究进展18 1.2.4 对不饱和键的氢化和生物活性方面的研究进展21 1.3 1.3 11..33 姜黄素生物活性及机理研究进展··································································21 1.4 1.4 11..44 展望······································································································23 第二章 设计思想及合成路线选择·············································································24 2.1 2.1 22..11 论文选题的目的和意义··············································································24 2.2 2.2 22..22 本课题设计思路·······················································································24 2.3 2.3 22..33 合成路线的确定·······················································································25 2.4 2.4 22..44 拟解决的问题··························································································25 第三章 实验部分································································