利川贝母化学成分研究.pdf

种及其产地、化学成分研究和药理研究状况。 关键词 贝母属;利川贝母了C一去甲一D-高苗体生物碱;利贝甲素了利贝新素湖贝啧 营厂5a一胆w烷ocholest-5-en-33(-oxylhexadecanoate ABSTRACT SixteencompoundsareisolatedfromthebulbsofFritillariaLichuanensis.Eightof themarealkaloids,andothersarenon-alkaloids.Thestructuresofalkaloidshavebeen establishedrespectivelytobe(20S,25S)5a,14a,17(3-cevanine-6p-hydroxy-3-one (hupehenirine,LB2);(20S,25S)5a,14a,173(-cevanine-3p-hydroxy-6-one(hupehenizine, LB4);(2011,25S)5a,14a-cevanine-33(,203(-dihydroxy-6-one(peiminine,verticinone, LB5);(2011,25R)5a,14a-cevanine-3p，6p-diol(lichuanine,LB6);(20S,25S)5x(,14a, 17p一cevanine-6-oxo-33(-O-(3-D-glucoside(hupehenizioside,LB7);(20S,25S)5a,14a, 173(-cevanine-6p一hydroxy-3p-O-3(-D-glucoside(hupeheninoside,LB8);(2011,25S)5a, 14a-cevanine-3p，6p-diolN-oxide(lichuanisinine,LB14);Andthestructuresof non-alkaloidshave been determined respectively to be cholest-5-en-3p-oxyl hexadecanoate (LBI);octadecanoicacid 伍B9);palmitic acid (LB10);ent- kauran-163(,17-diol(LB11);3(-sitosterol(LB15);daucoster(LB16)byspectroscopic analysis(IR,El-MS,FAB-MS,H-NMR,C-NMR,DEPT,H--HCOSY,HMQC, HMBC,NOES均andchemicalevidence.ThestructuresofLB12,LB13havenotbeen decided;ThestructureofLB3is5a,14a-cevanine-3(3-hydroxy-6-one,butits configurationisnotdecided.LB6,LB7,LB14arenovelalkaloids,LBlisfirstisolated arefirstisolatedfrom F.Lichuanensis. fromFritillaria,others The thesis also summarized new resourcesoftheChinesetraditional medicineBeimufrom 1980.Itlisted newspeciesofFritillariaandthestudieson theirthemicalconstituentsandbioactivities. Keywords FritillariaLichuanensis;C-nor-D-homosteroidalalkaloid; lichuanine;lichuanisinine;hupehenizioside;5a-cholestane;cholest-5-en-3日-oxyl hexadecanoate 致 谢 衷心感谢尊敬的导师吴继洲教授，在我读研期间从思想、学习及生活等各方面给 予我的精心指导、热情帮助和大力支持，吴老师严谨求实、奋发进取、精益求精的治 学态度使我受益非浅。 衷心感谢 日本摄南大学药学部藤多哲朗教授、栗尾和佐子助手，日本京都大学药 学部饭田彰助教授在波谱测试方面给予的热情支持和帮助。