莫西沙星和克拉霉素治疗社区获得性肺炎疗效观察.DOCVIP

临床医学论文-莫西沙星和克拉霉素治疗社区获得性肺炎疗效观察 【关键词】? 莫西沙星 　　摘要：目的：观察莫西沙星治疗社区获得性肺炎（CAP）的效果。方法：采用随机对照的方法，用克拉霉素为对照药，两组各30例，实验组予莫西沙星400mg口服每天一次，对照组予克拉霉素500mg口服每天二次，疗程7～14d。结果：莫西沙星组临床总有效率96.6%，克拉霉素组92.8%，两组细菌清除率分别为100%及92。3%，不良反应发生率分别为6.9%和10.3%。结论：莫西沙星临床疗效，不良反应与克拉霉素相似，是治疗CAP安全、有效的药物。 　　关键词：莫西沙星；克拉霉素；社区获得性肺炎 　　Study on the Effectiveness of Moxifloxacin and Clarithromycin in Treating Community Acquired Pneumonia 　　　Abstract：Objective： To evaluate the moxifloxacin effectiveness in treating community acquired pneumonia. Method: By using of randomized controlled clinical trial.60 patients were randomly assigned to the case group with moxifloxacin and the control group with clarithromycin, both groups were 30 cases, doses of both groups were taken orally 400mg/d qd and 500mg/d bid respectively, the therapy duration was 7～14 days. Result: The total clinical effective rate of both groups were 96.6% and 92.8%respectively,and bacteria eliminating rate were 100% and 92.8% respectively, and the rate of advrerse reaction were 6.9% and 10.3% respectively. Conclusion: There is no significanf difference in the clinical effectiveness and the rate of adverse reaction between two groups, so moxifloxacin is aslo an effective and safe antibacterial drug in treating community acquired pneumonia. 　　Key words：Moxifloxacin；Clarithromycin；Community acquired pneumonia??????????????????????????????????????????????????????????????????????????????????????????? 　　2003年8月至2004年8月本项研究以克拉霉素为对照药，观察莫西沙星和克拉霉素治疗 CAP 60例，以比较它们的疗效与安全性。 　　1 资料与方法 　　1.1 病例选择：采用随机对照的方法入选病例60例，年龄18～65岁，全部病例均符合CAP的诊断标准，无合并其它基础疾病，非孕妇或哺乳期妇女，均无对喹诺酮类及大环内酯类药物过敏史，50例为住院病人，10例为门诊病人，门诊病例均可随访。两组各有1例非药物不良反应因素退出治疗者，无法判定疗较及安全性属剔除病例，克拉霉素组有1例因不良反应而停药，列入安全性评价，但不作疗效评价。可作评价者两组共58例，实验组29例，男性19例，女性10例，年龄（56.8±11.36）岁，对照组29例，男性18例，女性11例，年龄（53.6±10.25）岁。2组在性别、年龄、感染严重程度，给药天数情况相仿，经统计学检验，P0.05。 　　1.2 给药方法和疗程：实验组予莫西沙星（拜复乐）400mg (一片)口服、每天一次，疗程7～14d，对照组予克拉霉素（诺邦）500 mg (二片)口服、每天二次，疗程7～14d。 　　1.3 观察项目与指标：临床观察：逐日记录疗程中患者临床症状和体征变化及出现的不良反应情况。细菌学检查及细菌药敏测定：入选患者尽可能用药前留取痰标本作细菌培养，鉴