吲哚布芬联合氯吡格雷治疗不稳定型心绞痛疗效观察.docVIP

吲哚布芬联合氯吡格雷治疗不稳定型心绞痛疗效观察 《湖南中医药大学学报》2012年第2期 徐维佳 陈敏锋 何小莉 余惠琼 （四川绵阳百信医院 621000） Clinic Analysis of Treatment on the unstable angina pectoris with Indobufen and clopidogrel Xu weijia, Chen minduo, Hexiaoli, Yu huiqiong (Baixin Hospital Mianyang Sichuan 621000) 摘要：目的：探讨吲哚布芬联合氯吡格雷治疗不稳定型心绞痛的临床疗效。方法：对入选的68例不稳定型心绞痛患者随机分为观察组（n=34）和对照组（n=34），观察组给予吲哚布芬和氯吡格雷，对照组给予阿司匹林和氯吡格雷,进行4周的观察。对两组治疗前后的心绞痛次数和持续时间进行比较，对两组间的临床疗效和安全性进行比较。结果：观察组和对照组与治疗前相比心绞痛发作次数和持续时间均有明显下降（P0.05），临床症状得到显著改善。两组间比较临床疗效相当（P0.05），观察组的安全性明显优于对照组。结论：吲哚布芬与氯吡格雷联合使用治疗不稳定型心绞痛临床疗效与阿司匹林联用氯吡格雷相当，具有更好的安全性。 关键词：吲哚布芬 氯吡格雷 不稳定型心绞痛 〔Abstract〕Objective To investigate the effects and safety of Xinbei- indobufen and clopidogrel in patients with unstable angina pectoris. Methods: 68 patients with unstable angina pectoris were selected and randomly divided into experiment group (n=34) and control group (n=34). The patients in experiment group were given anti-platelet indobufen and clopidogrel , in control group were given aspirin and clopidogrel for 4 weeks.The frequency and duration of unstable angina pectoris were compared between pre and post treatment. The clinical efficacy and safety were compared between experiment group and control group. Results: After treatment, the frequency and duration of unstable angina pectoris in both groups were lower than before (P0.05). The overall curative effects were similar in patients of the two groups(P0.05). But the experiment group was safe then control group. Conclusion: The clinical efficacy were similar in patients with unstable angina pectoris between Xinbei- indobufen、clopidogrel and aspirin、clopidogrel, but the aspirin and clopidogrel was more safe. Key words: Indobufen, clopidogrel, unstable angina pectoris, 不稳定型心绞痛(UAP)是一种冠心病的急性心脏事件，是急性冠状动脉综合征的重要组成部分，是介于慢性稳定性心绞痛和急性心肌梗死之间的中间临床综合征。±s） 组别 例数 发作频率（次/d） 持续时间（d） 治疗前 治疗后 治疗前 治疗后 对照组 34 5.9±1.7 3.1±1.2* 80.4±17.0 34.5±3.2 观察组 34 5.8±1.9 2.9±1.5* 79.8±16.9 32.4±1.8 * P0.05； 由表1可得：观察组给药4周后心绞痛的发作次数明显减少、持续时间明显缩短，P0.05存在显著性差异，说明吲哚布芬与氯吡格