吸烟对多发性硬化病人病情进展影响.pdfVIP

吸烟对多发性硬化病人病情进展影响 王运良1’ 张玉镇” 曾志磊∞ 张晓席1’ 尹红蕾1’ 王雨童1’ 耿同超3’ 1)解放军第148医院神经内科淄博2553002)郑州大学第二附属医院神经内科郑州4500143)清华大学玉泉医院 神经内科北京100049 【摘要】 目的探讨吸烟对多发性硬化(MS)病人病情进展的影响。方法 临床诊断为MS的病人，分为吸烟组、戒烟组和非吸烟组，根据临床和磁共振成像(MRI)特点，比较各组转化为继发进展型MS 的比例、脑实质分数(BPF)和T2高密度病灶体积变化。结果吸烟组与非吸烟组相比，扩展残疾状态量表评分(EDSS)和多 加，BPF减少。结论研究提示吸烟对MS进展有不利影响，吸烟可加速RRMS向SPMS的转化。 【关键词】多发性硬化；吸烟；疾病进展I核磁共振成像；转化 【文献标识码】A 【中图分类号】R744．5+1 【文章编号】1673—5110(2011)24—0010-03 Effectsof on ofthediseasewith sclerosis Yuzhen， WangYuliang，Zhang smokingprogress multiple patients Zhilei。et 148 PLA，Zibo255300，China Zeng a1．DepartmentofNeurology，theHospitalof To theeffectsof on ofthediseasewith sclerosis explore smokingprogress multiple patients．Methods [Abstract]Objective divided From 2005toDecember 364 with sclerosis(MS)inthree and 2010，We multiple hospital January followed-uppatients andnever tOtheirclinicaland resonanceim— themintothree smokers。ex-smokerssmokers．According magnetic groups。current theirdiseaseconversiontO rateofon characteristicsand therateof sclerosis，the aging compared secondaryprogressivemultiple inthebrain fractionandT2 lesionvolume．ResultsCurrentsmokershad study parenchymal hyperintense significantly change than intermsof statusscalescoreand sclerosis score，MSinsmok— worsenever-smokers multiple severity expandeddisability