胰酶肠溶片联合枳术宽中胶囊治疗功能性消化不良_医学论文.docVIP

胰酶肠溶片联合枳术宽中胶囊治疗功能性消化不良_医学论文 胰酶肠溶片联合枳术宽中胶囊治疗功能性消化不良_医学论文 作者：常廷民 范颖英 李贞娟 【摘要】目的 评价胰酶肠溶片联合枳术宽中胶囊在治疗功能性消化不良中的临床疗效和安全性。方法 将消化内科门诊中被确诊为功能性消化不良的90例患者随机分成A、B、C 3组，每组30人，A组口服胰酶肠溶片和枳术宽中胶囊，B组单口服枳术宽中胶囊，C组单口服胰酶肠溶片，疗程均为2周，比较各组治疗前后上腹胀、痛、早饱、嗳气临床症状改善情况并进行评分及治疗后临床症状消失时间。结果 治疗后3组患者的临床症状积分均显著低于治疗前（0.01或0.05）；B、C组患者治疗后临床症状改善率显著低于A组（0.01或0.05）；A组治疗后临床症状改善总有效率达到96%，均显著高于B、C组（0.05）；B、C组临床症状消失时间明显长于A组，差异有统计学意义（0.05）。结论 胰酶肠溶片联合枳术宽中胶囊治疗功能性消化不良起效更快，疗效更佳，安全性好，值得临床推广。 【关键词】 胰酶肠溶片 枳术宽中胶囊 功能性消化不良 【Abstract】 Objective： To evaluate the clinical efficacy and safety of treating functional dyspepsia using Pancreatin Enteric-coated tablet combine Zhizhukuanzhong capsule. Methods： 90 patients Diagnosed with FD in digestion medicine otpatient were randomly divided into A,B and C three groups, each group had 30 people. Group took orally the Pancreatin Enteric-coated tablet and Zhizhukuanzhong capsule， group B took Zhizhukuanzhong capsule only，and group C took Pancreatin Enteric-coated tablet only， the course of treatment is 2 weeks, compared the score and improvement of symptom like upper abdominal distention, pain, early satiety, bleching etc and the time that clinical symptoms disappear after treatment. Results: After treatment, the symptom scores of the three groups were significantly lower than before (plt0.01 or 0.05)The symptoms improvement rate in group B and C were significantly lower than group A after treatment (0.05) The total effective rate in group A reached 96% after treatment, higher than group B and C significantly (0.05) The disappeared time of symptoms in group B and C is significantly longer than group A. The difference have statistical significance (plt0.05) . Conclution: Pancreatin Enteric-coated Tablets joint operation of Zhizhukuanzhong Capsules has positive curative effect and higher safety in the treatment of functional dyspepsia, and is worthwhile for spreading in clinical. 【Key words】Pancreatin Enteric-coated tablet Zhizhukuanzhong capsule functional dyspesia 功能性消化不良（FD）是常见