独行菜属中药化学成分的研究进展.pdfVIP

独行菜属中药化学成分研究进展 李红伟, 郑晓珂, 冯卫生* 河南中医学院，河南 郑州 450046 摘要：独行菜属（Lepidium ）系十字花科植物，在地球上分布极广，资源丰富。 全球约 150 种，我国有 15 种。该属植物作为中药或民族药入药，许多国家都有 记载。现已从该属植物中分离得到了异硫氰酸和硫苷类成分，以及强心苷、黄酮、 三萜、甾醇、鞣质、香豆素、生物碱、酚酸、挥发油、脂肪油、氨基酸等成分。 该属植物对心血管、高血脂、糖尿病、癌症等疾病具有显著功效，所含的成分具 有降血压、细胞毒、降血糖、提高生育力、改善性功能和抗氧化等药理活性。对 独行菜属中药的化学成分研究进行分类汇总和比较，为进一步研究该属中药的药 效物质基础提供参考。 关键词：独行菜属；异硫氰酸；生物碱；玛咖酰胺；黄酮；强心苷 Research progress in chemical constituents of Lepidium LI Hong-wei, ZHENG Xiao-ke, FENG Wei-sheng Henan University of Traditional Chinese Medicine, Zhengzhou 450046, China Abstract: Lepidium, belonging to Cruciferae (Brassiaceae) family, is widely distributed in world which has around 150 species, 15 species in China. This genus as Chinese Traditional Medicine or ethnic medicine have been described in the literature. So far large quantity of unique glucosinolate degradation products such as isosulfocyanic acids and thioglycosides have been isolated from the plants, together with other types of active principles, such as cardiac glycosides, flavonoids, terpenoids, sterols, tannins, cumarins, alkaloids, phenolic acids, volatile oils, fatty oils, and amino acids etc. The plants have the significant effects on cadiovascular diseases, hyperlipemia, diabetes mellitus, cancer, and so on. Their active principles have entitled the plant to serve several different bioactivities including antihypertensive, cytotoxic, hyperglycemic, improving fertility and sexual function, and antioxidative effects. This paper reviews in detail the categorization of chemical constituents from Lepidium . Key words: Lepidium ; isosulfocyanic acid; alkaloids; macmides; flavonoids; cardiac glycosides 独行菜属为十字花科草本植物，全球约150 种，资源分布极为丰富，其中我 国有15 种，南北均有分布。该属植物作为中药或民族药入药，许多国家都有记 载。如独行菜（L. apetalum ）子为中药葶苈子，玛咖（L. meyenii ）为秘鲁人参， 家独行菜（L.