NEDD9在食管鳞状细胞癌中表达的意义.pdfVIP

现代肿瘤医学 2015年4月 第23卷第8期 MODERNONCOLOGY，Apr．2015，VOI． ． ·1075· NEDD9在食管鳞状细胞癌中表达的意义 韦 林 ，周 斌 ，姜建涛 ，张 晋 ，孔冉冉 ，张丹杰 TheclinicalsignificanceofNEDD9expressioninesophagealcarcinoma WeiLin ，ZhouBin，JiangJiantao，ZhangJin，KongRanran，ZhangDanjie DepartmentofCardio—Thoracic5“rge ，theSecondAffiliatedHospital，MedicalCollegeofXianJiaotongUniversity，ShaanxiXian 710004，China；Departmentof Cardio—Thoracics“rg柳y，XianTuberculosisandThoracicTumorHospital，ShaanxiXian710061， China． A【bstract】 Objective：Toexploretheexpressionofneuralprecursorcellexpressed，developmentallydown—regula— ted9(NEDD9)andit clinicalsignificanceinesophagealcarcinoma．Methods：ImmunohistochemistryandReal— timepolymerasechainreactionwereusedtodetecttheexpressionofNEED9in40esophagealcancertissuesandadja— centnormaltissues．AndtherelationshipbetweentheNEDD9expression andtheclinicopathologycalcharacteristics wasanalyzed．Reslllts：ThepositivityratesofNEDD9 proteinswere77．5％ intheesophageal cancertissues，and 25．0％ inadjacentnormaltissues．ThelevelsofNEDD9mRNAexpressionwere1．704±0．36inesophagealcancer tissues．and0．843±0．526inadjacentnormaltissues．TheexpressionsofNEDD9proteinandmRNAinesophageal cancertissueswerehigherthanthatintheadjacentnormaltissues．TheexpressionofNEDD9inesophagealcarcinoma wascorrelatedwithclinicalstageandnodemetastasis，whilenocorrelatedwithage，genderandpathologicalstaging． Conclusion：NEDD9expression inesophagealcarcinomatissueishigherthan innormalesophagealtissue，itwasas— soeiatedwithtumorinvasionandmetastasis．Itshouldbeapotentialbiomarkerofesophageal carcinoma． K【eywords】esophagealcarcinoma；immunohistochemistry；NEDD9；RT—PeR ModernOncology2015，23(08)：1075—1077 【摘要】 目的：探讨NEDD9在食管鳞癌中表达的意义及与肿瘤发生发展和转移的关系。方法：采用免疫组 化方法及 Real—timePCR技术检测NEDD9在40例食管鳞癌癌组织、癌旁正常组织中的表达情况，并分析 NEDD9的表达与肿瘤临床病理特征之间