凋亡相关基因Bax、FasL、c-FLIP在浆液性卵巢癌中的表达.pdfVIP

马 莉，等 凋亡相关基因Bax、FasL、e—FLIP在浆液性卵巢癌中的表达 [1O] BenSahraI，TantiJF，BostF．Thecombinationofmefforminand2 tion in papillary thyroid carcinoma is associated with glucose — 。 deoxyglucoseinhibitsautophagyandinducesAMPK ——depend— transporter1overexpression[J]．Thyroid，2012，22(4)：377— entapoptosisinprostatecancerceil[J]．Autophagy，2010，6 382． (5)：670—671． [13] 刘睿，王晓楠，张薇，等．PKM2siRNA对人甲状腺乳头状癌细 [11] 俞晓燕，孙子林．GLUT1的研究进展[J]．现代中西医结合杂 胞生长和增殖的影响[J]．现代肿瘤医学 ，2014，22(2)：278— 志，2012，21(30)：3411—3414． 282． [12] GrabellusF，Worm K。SchmidKW ，eta1．TheBRAFV600Emuta- (编校：徐萌) 凋亡相关基因Bax、FasL、a—FLIP在浆液性卵巢癌中的表达 马 莉，康石清，苗 莉，靳耀锋 ，康安静 ExpressionofapoptosisrelatedgeneBox，FasL，C—FLIPinserousovariancarcinoma MaLi，KangShiqing，MiaoLi，JinYaofeng，KangAnjing DepartmentofPathology，TheSecondAffiliatedHospital，XianJiaotongUniversity，Shaanxi 缸n710004，China． A【bstract】 Objective：ToexploreexpressionsofBax，FasL，C—FLIPinserousovariancarcinomaandtheirclinical significances．M ethods：WeexaminedexpressionsofBax，FasL，C—FLIPin16serouscystadenoma，25borderlinese— rouscystadenoma，48serouscystadenocarcinomatissueswithSP immuohistochemicalmethod nadreal—timePCR． Results：ProteinandmRNA expressionsofBax，FasL，C—FLIPinserouscystadenocarcinomawassignificantlystron— gerthna thatinserouscystadenomaandborderlineserouscystadenoma(P0．05)．Conclusion：ProteinandmRNA expressionsofapoptosisrelatedgeneBax，FasL，e—FLIPinserousovarina carcinomaareincreased，which isinvolved inthedevelopmentofovarina cancer．Thiscouldalsoprovidesomenew tragetsfortheclinicalpreventionofovarian cancer． 【Keywords】serouscystadenocarcinoma；Bax；FasL；c—FLIP；apoptosis ModemOncology2015，23(07)：0904—0907 摘【要】 目的