中药口服渗透泵制剂的研究进展_黄涛.pdfVIP

• 642 • 现代药物与临床 Drugs Clinic 第 27 卷 第 6 期 2012 年 11 月 中药口服渗透泵制剂的研究进展 1 1 1 2* 黄 涛 ，孙燕燕 ，林 宏 ，张铁军 1. 天津市儿童医院，天津 300074 2. 天津药物研究院，天津 300193 摘 要：通过查阅近几年国内外有关中药口服渗透泵制剂相关的文献，发现在中药单一成分、有效部位和复方等方面均有研 究报道，内容主要是渗透泵制剂的制备工艺和体外释放度评价，也有制剂缓释作用综合评价方法和体外释放机制的探索，综 述了近年来中药口服渗透泵制剂的研究进展。随着中医药基础研究的深入，渗透泵制剂技术的发展，中药口服渗透泵制剂研 究有着广阔的发展前景。 关键词：中药；渗透泵；控释制剂；零级释放；制备工艺 中图分类号：R283.6 文献标志码：A 文章编号：1674 - 5515(2012)06 - 0642 - 05 Progress in oral osmotic pump preparations of Chinese materia medica 1 1 1 2 HUANG Tao , SUN Yan-yan , LIN Hong , ZHANG Tie-jun 1. Tianjin Childrens Hospital, Tianjin 300074, China 2. Tianjin Institute of Pharmaceutical Research, Tianjin 300193, China Abstract: This paper searched relevant literatures with oral osmotic pump preparation, the results showed that the studies on the monomer compounds, effective fractions, and compound prescriptions of Chinese materia medica (CMM) have been reported. The reports are mainly focused on the preparation technology, evaluation on in vitro release, the comprehensive evaluation method of sustained-release preparation, and the mechanism of in vitro release. The research progress in oral osmotic pump preparations of CMM in recent years is reviewed. With the further development of basic research of traditional Chinese medicines and preparation technology of osmotic pumps, the studies on the oral osmotic pump preparations of CMM will have the broad developing prospects. Key words: Chinese materia medica (CMM); osmotic pumps; sustained-release preparation; preparation technology 渗透泵型控释制剂作为缓控释制剂的典型代 较晚，是以中药的有效成分、有效部位和复方为研 表，以渗透压为主要推动力，具有零级释药的特征， 究对象，进行渗透泵制剂的开发研究。由于中药成 是一种比较理想的制剂技术。由于渗透泵控释制剂 分复杂、含量较低、药效评价困难等一系列瓶颈问 以零级动力学控制药物释放，所以几乎不受胃肠道