腹腔注射乙酰唑胺对大鼠氧惊厥潜伏期的影响.pdfVIP

Acta Physiologica Sinica, August 25, 2005, 57 (4): 461-466 461 * 200433 (maleic dialdehyde, MDA)(acetazolamide, ACZ) ACZ (indomethacin, IND) (1)ACZ ( 7.5 mg/kg ) (P 0.05) IND IND (20 mg/kg ) 30 min ACZ (7.5 mg/kg ) ACZ (P0.05) (2) ACZ 7.5 mg/kg 6 16 min MDA (P0.01 P0.05); IND MDA IND ACZ MDA (P0.01, P 0.05) ACZ IND Q 4 7 9 Influence of acetazolamide given intraperitoneally on the latency to hyperbaric oxygen-induced convulsion of rats HUANG Jun-Long, LIAN Qing-Lin, JIANG Chun-Lei, GUO Ming-Zhu, SUN Xue-Jun* Department of Nautical Medicine, Faculty of Naval Medicine, the Second Military Medical University, Shanghai 200433, China Abstract: The purpose of the present study was to explore the relation between the modulation of cerebral blood flow and the latency of hyperbaric oxygen-induced convulsion. There were two parts in this study. First, the effect of acetazolamide or (and) indomethacin on the latency of hyperbaric oxygen-induced convulsion was observed. Seventy Sprague-Dawley (SD) rats were randomly divided into 7 groups: the acetazolamide 200, 20, 10, 7.5, 5, 2.5 mg/kg body weight and normal saline (NS) group. Forty rats were divided into 5 groups: indomethacin 20, 10, 5, 2.5 mg/kg body weight and NS groups. Another 40 rats were divided into 5 groups which were administered with indomethacin in the dose of 0 mg/kg (NS), 0 mg/kg (NS), 5, 10 and 20 mg/kg body weight. Thirty min later the first group was given NS, and all the other four groups were given acetazolamide with a dose of 7.5 mg/kg body weight. The animals were given acetazolamide or (and) indomethacin intraperitoneally, and 20 min later they were exposed to the pressure of 6 ATA (absolute atmosphere) of pure oxygen. The tim