冠心苏合胶囊对急性心肌梗死大鼠肌钙蛋白T及心肌酶的影响.pdfVIP

Effect of Guanxinsuhe Capsule of cTn-T and Myocardial enzyme on Acute Myocardial Infarction in Rats HAO DI, LI XU,KANG LI,WANG ZI,WANG LEI, LV NAN,CHONG Ying-ying,CHEN Wei-ping （Tianjin Institute of Medical and Pharmaceutical Science，Tianjin 300020，china） [Abstract] objective: To evaluate the dynamic changing of cTn-T and To observe the treatment effect of Guanxinsuhe capsule on acute myocardial infarction （AMI ） in rats and to investigate its mechanism. Methods : Rats were selected to establish the models of acute myocardial infarction. The rats were divided randomly into five groups and treated with pure water、high-dose guanxinsuhe (0.8g/kg) 、 low-dose guanxinsuhe (0.4g/kg)、captopril respectively for 5 days, then AMI model were established .Determined cTn-T 、AST 、CK、CK –MB after ligating 31h . Results: the area of myocardial infarction in the guanxinsuhe high dosage group was reduced, cTn-T and AST decreased, showing a statistical significance compared with the model group (P0.05, P0.01 ，P0.01).The effect of high-dose guanxinsuhe and low-dose Guanxinsuhe on ECG in acute myocardial infarction rats was observed, the heights of ST segment were reduced just after ligating 0h and 31h. Conclusion: Guanxinsuhe has significant effect on myocardial infarction, It treats myocardial infarction through regulating cTn-T and AST . [Key words] Troponin ；Myocardial enzyme ;Guanxinsuhe Capsule; Myocardial infarction ; rat 冠心苏合胶囊由苏合香、冰片、乳香（制）、檀香、青木香五味中药组成，具 有芳香开窍，行气活血，宽胸止痛之功能,用于治疗心绞痛、胸闷憋气、心肌梗 死等病症。评价心肌损伤进程及预后的重要手段就是选定心肌损伤标志物，以往 研究人员倾向于AST、CK、CK-MB等心肌酶的测定，但这些指标的测定有一定的局 限性和不稳定性。cTn－T作为一种新型急性心肌梗死诊断标志物，由于其出现时 间早、高特异性、高敏感性，因而具有较大的临床应用价值，成为临床上早期判 断心肌梗死的重要依据[1]。cTn－T在心肌梗死病变过程中呈动态变化，对其达峰 时间的确定具有指导性意义 目前，冠心苏合胶囊对心肌梗死中cTn－T变化影响 鲜有文献报道，为此，本文利用心肌梗死大鼠模型研究cTn－T在心肌梗死中变化 规律并找出其峰值的敏感时间来观察冠心苏合胶囊对心肌梗死的治疗作用，