血浆血管内皮生长因子尿微量白蛋白及β2微球蛋白与过敏性紫癜患儿早期肾损伤的相关性.docVIP

血浆血管内皮生长因子、尿微量白蛋白及β2-微球蛋白与过敏性紫癜患儿早期肾损伤的相关性 　　作者：厉洪江,张迎辉,刘翠华,王小稳,田明　　作者单位：郑州市儿童医院肾内科，河南 郑州 450053载 　　【摘要】 目的 探讨血浆血管内皮生长因子(VEGF)、尿微量白蛋白(MA)及Β2-微球蛋白(Β2-MG)与过敏性紫癜(HSP)早期肾损害的相关性。方法 73例HSP患儿分为皮肤型组23例、混合型组28例和紫癜性肾炎(HSPN)型组22例;对照组23例为健康体检者;治疗后组25例为治疗2周后临床无阳性症状、体征，出院前复查尿常规及24 h尿蛋白定量正常者。采用酶联免疫吸附测定-ABC法(ABC-ELISA)测定血浆VEGF，采用放射免疫分析法测定尿MA及Β2-MG。结果 HSPN型组血浆VEGF、尿MA及Β2-MG水平明显高于皮肤型组和混合型组(P0.05，P0.01)，治疗后组血浆VEGF、尿MA和Β2-MG明显高于对照组(P0.05);HSP患儿VEGF和MA呈正相关(r=0.444，P0.05);VEGF和Β2-MG呈正相关(r= 0.275，P0.05)。结论 血浆VEGF、尿MA及Β2-MG参与了HSPN的发病过程，是早期HSP并发肾损伤的敏感指标。 　　【关键词】 过敏性紫癜;血管内皮生长因子;Β2-微球蛋白 　　Correlation of plasma vascular endothelial growth factor,urine microalbumin and Β2-microglobulin with early renal injury in children with Henoch-Schenlein purpura　　LI Hong-jiang,ZHANG Ying-hui,LIU Cui-hua,et al　　(Department of Nephrology,Children′s Hospital of Zhengzhou,Zhengzhou 450053,China) 　　Abstract: Objective To explore the correlation of plasma vascular endothelial growth factor (VEGF),urine microalbumin(MA) and Β2-microglobulin(Β2-MG)with early renal injury in children with Henoch-Schenlein purpura (HSP).Methods Seventy-three cases of HSP were divided into skin type group(23 cases),mixed pattern group(28 cases) and Henoch-Schonlein purpura nephritis(HSPN) group(22 cases).Twenty-three of control group were healthy children.Twenty-five cases of post-treatment group had negative symptoms，normal urine analysis result and 24 h urine protein after 2 weeks treatment.Plasma VEGF was detected with enzyme-linked immunosorbent assay,Urine MA and Β2-MG were detected with radioimmunoassay.Results The levels of plasma VEGF,urine MA and Β2-MG in HSPN group were higher than these in skin type group and mixed pattern group(P0.05，P0.01),and these in post-treatment group were higher than these in control group(P0.05).It was positive correlation between VEGF and MA(r=0.444，P0.05),it was positive correlation between VEGF and Β2-MG(r=0.275，P0.05).Conclusion VEGF,MA and Β2-MG may involve in the development