胎牛皮脱细胞真皮基质作为组织工程神经支架有应用前景？.docVIP

胎牛皮脱细胞真皮基质作为组织工程神经支架有应用前景？ 胎牛皮脱细胞真皮基质作为支架材料，可为神经再生领域提供大量天然的、具有良好生物相容性和可降解性的生物支架。 来自中国甘肃农业大学的冯玉萍所在团队以胎牛皮开发脱细胞真皮基质为组织工程神经支架，以期构建组织工程化神经。研究显示，人骨髓间充质干细胞在胎牛皮脱细胞真皮基质上能够成功向成熟神经细胞分化，并建立了突触联系，形成了神经网络结构。充分体现了以胎牛皮开发脱细胞真皮基质为支架构建组织工程神经，具有可行性和可操作性，揭示了胎牛皮脱细胞真皮基质在神经再生领域的应用前景。文章发表在《中国神经再生研究（英文版）》杂志2014年11月第22期。 扫描电镜下观察，胎牛皮脱细胞真皮基质基底有一些3-10 μm尺寸的小孔和一些纤维交织的网状结构Article: Differentiation of mesenchymal stem cells into neuronal cells on fetal bovine acellular dermal matrix as a tissue engineered nerve scaffold, by Yuping Feng1, 2, Jiao Wang3, Shixin Ling2, Zhuo Li2, Mingsheng Li2, Qiongyi Li2, Zongren Ma2, Sijiu Yu1 (1 Animal Medicine College of Gansu Agriculture University, Lanzhou, Gansu Province, China; 2 Gansu Provincial Animal Cell Engineering Center; Key Laboratory of Bioengineering Technology of State Ethnic Affairs Commission, Life; Science and Engineering College of Northwest University for Nationalities, Lanzhou, Gansu Province, China; 3 Laboratory of Molecular Neurobiology, Institute of Systems Biology, Shanghai University, Shanghai, China) Feng YP, Wang J, Ling SX, Li Z, Li MS, Li QY, Ma ZR, Yu SJ. Differentiation of mesenchymal stem cells into neuronal cells on fetal bovine acellular dermal matrix as a tissue engineered nerve scaffold. Neural Regen Res. 2014;9(22):1968-1978 欲获更多资讯： Neural Regen Res Fetal bovine acellular dermal matrix as a tissue engineered nerve scaffold Bovine acellular dermal matrix can be made into a large amount of natural biological scaffolds with good biocompatibility and degradability for use in the field of neural regeneration. Yuping Feng, Animal Medicine College of Gansu Agriculture University, China used bovine acellular dermal matrix as tissue-engineered nerve scaffold to construct tissue-engineered nerve. They found that human bone marrow mesenchymal stem cells differentiated on fetal bovine acellular dermal matrix into mature nerve cells, and neural network formed by synaptic connection. These results suggest that it is feasible and manipula