Prognostic Significance of Biallelic Loss of PTEN in Clear Cell Renal Cell Carcinoma》.pdf

Investigative Urology Prognostic Significance of Biallelic Loss of PTEN in Clear Cell Renal Cell Carcinoma Hee Jin Lee, Ho Yun Lee,* Jeong Hee Lee, Hajeong Lee, Guhyun Kang, Joon Seon Song, Jun Kang† and Ju Han Kim Program for Certified Physicians in BioMedical Informatics, Korean Society of Medical Informatics (HJL, HYL, JHL, HL, GK, JSS, JK), Department of Pathology, Asan Medical Center, University of Ulsan College of Medicine (HJL, JSS), Department of Internal Medicine (HL) and Systems Biomedical Informatics National Core Research Center (JHK), Seoul National University College of Medicine, Department of Pathology, Inje University Sanggye Paik Hospital, Inje University College of Medicine (GK), Department of Radiology and Center for Imaging Science, Samsung Medical Center, Sungkyunkwan University School of Medicine (HYL) and Division of Biomedical Informatics, Seoul National University Biomedical Informatics (JHK), Seoul and Departments of Pathology, Pusan National University Yangsan Hospital, Pusan National University School of Medicine (JHL), Yangsan and Inchun St. Mary’s Hospital, Catholic University of Korea (JK), Inchun, Republic of Korea Purpose: We investigated the clinical implications of biallelic loss of PTEN Abbreviations in clear cell renal cell carcinoma and whether PTEN biallelic loss would induce and Acronyms p53 dependent cellular senescence. AJCC ¼ American Joint Committee on Cancer Materials and Methods: Data were obtained using the CGDS-R package from the TCGA data set kirc_tcga_pub. PTEN allelic status was classified into ccRCC ¼ clear cell renal cell 3 groups, including biallelic PTEN loss (homo