吡唑并嘧啶酮的合成进展有机化学.pdfVIP

DOI: 10.6023/cjoc201304007 综述与进展 有机化学 Chinese Journal of Organic Chemistry REVIEW 吡唑并嘧啶酮的合成进展 杨绪红 曹晓蓓 金小红 吴鸣虎* (湖北科技学院核技术与化学生物学院 咸宁 437100) 摘要 吡唑并嘧啶酮化合物广泛存在于自然界. 自从1888 年合成第一个吡唑并嘧啶酮以来, 吡唑并嘧啶酮的合成与应 用研究越来越活跃. 一些吡唑并嘧啶酮化合物被应用到常见疾病的治疗上, 可谓珍贵药物发现史上的明珠. 一个多世 纪以来, 各种合成吡唑嘧啶酮化合物的方法层出不穷. 但是, 有关吡唑嘧啶酮的合成的专题综述尚未见文献报道. 本 文从合成方法学的角度对吡唑并嘧啶酮的合成作一全面综述. 关键词 1H-吡唑并[3,4-d]嘧啶-4(5H)-酮; 1H-吡唑并[3,4-d]嘧啶-6(7H)-酮; 1H-吡唑并[4,3-d]嘧啶-5(4H)-酮; 1H-吡唑并 [4,3-d]嘧啶-7(6H)-酮; 吡唑并嘧啶酮; 合成 Progress in Synthesis of Pyrazolopyrimidinone Yang, Xuhong Cao, Xiaobei Jin, Xiaohong Wu, Minghu* (Faculty of Nuclear Technology Chemistry and Biology, Hubei University of Science and Technology, Xianning 437100) Abstract Pyrazolopyrimidinone compounds are widely found in nature. Since the first pyrazolopyrimidinone was synthe- sized in 1888, synthesis and application of pyrazolopyrimidinones have been more and more active. Some pyrazolopyrimidi- nones are applied to the treatment of commom diseases, and are called the crown jewels in drug discovery history. For more than one century, various synthetic methodologies concerning pyrazolopyrimidinone have been developed. However, no spe- cific review about pyrazolopyrimidinones was present. This review comments the synthesis of pyrazolopyrimidinone from the point of view of the synthetic methodology. Keywords 1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one; 1H-pyrazolo[3,4-d]pyrimidin-6(7H)-one; 1H-pyr