氮自由基环化反应的新进展有机化学.pdfVIP

2011 年第 31 卷 有 机 化 学 Vol. 31, 2011 第 4 期, 453～465 Chinese Journal of Organic Chemistry No. 4, 453～465 ·综述与进展· 氮自由基环化反应的新进展 徐小岚 a,c 万 薪 b 耿 烨 b 张家松 b 许华建*,b,c (a 安徽医科大学基础医学院 合肥 230032) (b 合肥工业大学化学工程学院 合肥 230009) (c 可控化学与材料化工安徽省重点实验室 合肥 230009) 摘要 三十年前, 自由基反应在有机合成中的应用已经非常普遍, 但其主要集中在碳自由基的应用上, 而杂原子自由 基却一直得不到发展. 氮自由基环化反应是在近十年内才逐步应用到有机合成中的, 它对合成一系列的氮杂环化合物 有重要的意义, 如内酰胺类、吡咯烷类、生物碱类物质等. 从四个方面对氮自由基经环化反应合成多种氮杂环化合物 的研究进展做一介绍. 关键词 自由基反应; 有机合成; 氮自由基; 环化反应; 氮杂环 Recent Progress in Nitrogen-Centered Radical Cyclizations Xu, Xiaolana,c Wan, Xinb Geng, Yeb Zhang, Jiasongb Xu, Huajian*,b,c (a College of Basic Medicine, Anhui Medical University, Hefei 230032) (b School of Chemical and Engineering, Hefei University of Technology, Hefei 230009) (c Anhui Key Laboratory of Controllable Chemistry Reaction Material Chemical Engineering , Hefei 230009) Abstract Radical reactions were applied widely in organic synthesis about three decades ago, but most of the synthetic applications have concerned on carbon-centered radicals, while heteroatom-centered radicals have received much less scrutiny. The cyclizations of nitrogen radicals in organic synthesis have gained in- creasing attentions in the past few years, because it is very important for synthesizing N-heterocycle com- pounds, such as lactams, pyrrolidines, alkaloids and so on. This review describes the recent progress of ni- trogen radicals on the cyclization to form various