氯化铯催化羧酸钠(钾)与α-氯代乙酸酯及溴(氯)代烃反应有机化学.pdfVIP

DOI: 10.6023/cjoc201208010 研究简报 有机化学 Chinese Journal of Organic Chemistry NOTE 氯化铯催化羧酸钠(钾)与α-氯代乙酸酯及溴(氯)代烃反应 刘文奇a 奇建永b 陈锦杨b 李宁波b 邱仁华b 许新华*,b a ( 湘南学院湘南稀贵金属化合物及其应用湖南省重点实验 郴州 423000) (b 湖南大学化学化工学院 长沙 410082) 摘要 以DMF 为溶剂, 在催化量氯化铯存在下, 羧酸钠(钾)与α-氯代乙酸酯在室温下反应及其与溴(氯)代烃在60 ℃反 应, 分别形成对应的羧酸(α-烷氧甲酰) 甲酯与羧酸酯, 产率 90% 以上, 讨论了催化机理. 关键词 氯化铯; 羧酸钠(钾); α-氯代乙酸酯; 酯化反应 Cesium Chloride Catalysized the Reaction of Sodium (Potassium) Carboxylates with Alkyl Bromides (Chlorides) Liu, Wenqia Qi, Jianyongb Chen, Jinyangb Li, Ningbob Qui, Renhuab Xu, Xinhua*,b a ( Hunan Provincial Key Laboratory of Xiangnan Rare-Precious Metals Compounds Research and Application , Xiangnan University, Chenzhou 42300) b ( College of Chemistry Chemical and Engineering, Hunan University, Changsha 410082) Abstract In the presence of catalytic amounts of cesium chloride, using DMF as solvent, sodium (potassium) carboxylates reacted with α-chloroacetates at room temperature or reacted with alkyl bromides (chlorides) at 60 ℃ to give the correspond- ing (α-alkoxyformacyl)methyl carboxylic esters and carboxylic esters in ＞90% yields. The catalytic mechanism was dis- cussed. Keywords cesium chloride; sodium (potassium) carboxylates; alkyl bromides (chlorides); esterification 铯离子能活化与之结合的阴离子, 这是因为铯离子 味和芳香均来源于酯.