化痰通腑汤治疗血性中风急性期痰热腑实证的临床研究.pdfVIP

Clinical Study of “Hua Tan Tong Fu Decoction” in Treating acute stage of ischemic stroke with phlegm-heat and sthenia of fu-organ Speciality: Internal Medicine of TCM Author:Wang Lei Tutor: prof.You Ke Abstract Objective ：To study clinical efficacy of “Hua Tan Tong Fu Decoction” in treating acute stage of ischemic stroke with phlegm-heat and sthenia of fu-organ and to discuss the mechanism of this therapy.Methods ：60 cases were randomly divided into 2 groups，30 cases in treatment group and 30 cases in control group. Routine Western medicine were administrated to the cases of control group. “Hua Tan Tong Fu Decoction” and routine Western medicine were administrated to the cases of treatment group. The treatment cycle is 14days.Changes ofclinical neurological defects of the two groups、Activities of Daily Living (ADL) 、Syndromes of Traditional Chinese Medicine(TCM) 、Blood-lipid 、 Endothelial Function 、Fibrinogen and other lab indexes were observed before and after treatment.Results ：14days later, we found total effective rate of treatment group was 93.33%，which had an predominant difference compared with control group (P0.05). The scores of clinical neurological defects,Syndrome Integrals of (TCM) and the scores of ADL all had significant differences in treatment group before and after treatment (P0.05), those in treatment group were signfiantly better than in control group(P0.05). ET 、TXB2 、 Fg levels were decreased and 6-keto-PGF1a, NO levels were increased more significantly in treatment group, compared with control group(P0.05).TC 、TG、HDL-C levels were all improved,but there were no significant differences between the two groups(p0.05). LDL-C level was decreased more significantly in treatment group, compared with control group(P0.05).C