Preparation+of+Pixantrone%2fPoly(γ-glutamic+acid)+Nanoparticles+through+the+Complex+Self-assembly+for+Oral+Chemotherapy.pdfVIP

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2016-05-13 发布于安徽
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Preparation+of+Pixantrone%2fPoly(γ-glutamic+acid)+Nanoparticles+through+the+Complex+Self-assembly+for+Oral+Chemotherapy.pdf

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Preparation of Pixantrone/Poly(γ-glutamic acid) Nanoparticles through the Complex Self-assembly for Oral Chemotherapy * * Lili Meng, Bing Ji, Wei Huang, Dali Wang, Gangsheng Tong, Yue Su, Xinyuan Zhu, Deyue * Yan ––––––––– L. Meng, Prof. W. Huang, Prof. X. Zhu, Prof. D. Yan School of Chemistry and Chemical engineering, State Key Laboratory of Metal Matrix Composites, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai, 200240, P.R. China E-mail: hw66@sjtu.edu.cn, dyyan@sjtu.edu.cn D. Wang, G. Tong, Y. Su Instrumental Analysis Center, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai, 200240, P.R. China B. Ji Huzhou Teachers College, 1 Xueshi Road, Huzhou 313000, P. R. China E-mail: hxxjb@hutc.zj.cn ––––––––– A facile and green approach is reported to construct pixantrone/poly(γ-glutamic acid) nanoparticles (PIX/γ-PGA NPs) through the complex self-assembly of polyelectrolyte γ-PGA and anticancer drug pixantrone dimaleate (PDM) in water as a drug delivery system for cancer therapy by oral administration. The complex self-assembly behavior is investigated in detail by UV-Vis, FTIR, DLS, TEM, and ζ potential measurements. The results demonstrate that PDM can interact with γ-PGA by ionic interaction to form NPs conveniently. Furthermore, the size of NPs can be controlled by adjusting the solution volume ratio (SVR) of PDM to γ-PGA. In vitro release studies show a pH-dependent release behavior of PIX/γ- PGA NPs under the simulated pH environments of the gastrointestinal (GI) tract. Flow cytometry and CLSM analysis illustrates that PIX/γ-PGA NPs can be internalized effectively - 1 - by vivid Lovo cells and mainly accumulate in the cytoplasm. By means of MTT assay against Lovo cells in vitro, PIX/γ-PGA NPs exhibit a remarkably enh