Meta-analysis 演示.pptVIP

Soy or soy isoflavone intake is associated with lower lung cancer risk: a system review and meta-analysis By ywshui, a dxyer Jan 4, 2012 Note: This slide is for your own and only personal use. Any other use is unpermitted. 仅供个人学习交流使用，请勿作它用！ Outline PartⅠ Hypothesis 假设形成 PartⅡ Summary of Epidemiologic evidence 总结证据 Part Ⅲ Conclusions 得出结论 Background 文献： Yang WS, et al. Soy intake is associated with lower lung cancer risk: results from a meta-analysis of epidemiologic studies. American Journal of Clinical Nutrition 2011; 94(6): 1575-83. 全文/摘要链接：/content/early/2011/11/08/ajcn.111.020966.abstract 路透社等媒体对该文的报道链接： /article/2011/11/17/us-soy-eaters-idUSTRE7AG2KHypothesis（假设形成） 作者阅读文献发现膳食中的异黄酮与激素相关的癌症发生风险的降低和良好的预后有关，该作用是通过雌激素受体（ER）信号通路介导，如乳腺癌，子宫内膜癌，卵巢癌等。而大豆及其制品是膳食异黄酮最主要的来源，因此豆类食品可能对激素相关癌症有保护作用。正常肺或者肺癌组织中是否也存在雌激素受体呢？若有，豆类食品是否也与它的发生或者预后有关？ Hypothesis（假设形成） 上图显示不仅在肺癌组织中存在ER，而且正常的肺组织中同样也显示阳性。进一步复习机制学文献（动物实验或者体外实验），支持豆类食品对肺癌及其预后的保护作用是通过ER信号通路所介导； 不仅如此，豆类食品中的大豆异黄酮还可以通过EGFR信号通路对肺癌的发生起到预防作用，且性别中的女性、亚洲人群、肺腺癌、非吸烟群体与EGRR突变有关。 Hypothesis（假设形成） 于是作者形成以下假设： 1) Soy or soy isoflavone intake is associated with lower lung cancer risk, particularly in 2)women, Asians, lung adenocarcinoma, and never smokers 并通过总结流行病学观察性研究的证据（即系统综述和meta分析）来验证以上假设 Data sources and searches PubMed, EMBASE, and the Cochrane Library (from their inception to February 2011) Both case-control and cohort studies that assessed soy consumption and lung cancer risk. Study selection criteria A published article was included if it 1) had a case-control or cohort design 2) evaluated the association between soy or soy isoflavones and lung cancer risk, and 3) reported the OR or RR and its 95% CI. Quality assessment An improved 10-star system on the basis of the Newcastle-Ottawa Scale selection of the study groups, the comparability of the groups, the ascertainment of exposure and outcome, and the methods used in data analysis (Item added) (Yang WS et al. Am J Clin Nutr 2011) A study with data