中药银屑1号对体外培养中性粒细胞分泌NE、trappin2影响.pdfVIP

影响，进一步观察NE／Trappin一2的平衡与银屑病的关系。 结果： NE的实验结果是：与生理盐水组比较，银屑0，1，2，3号、雷公藤组均具有统计学 差异(尺O．05)；中药银屑组与雷公藤组比较：银屑0号组不具有统计学差异；银屑 1，2，3号均具有统计学差异(尺O．05)。Trappin一2的实验结果是：随着中药含药血清 浓度的降低，trappin-2的表达水平逐渐升高。统计结果显示：与生理盐水组比较， 银屑O，l，2，3号、雷公藤组均具有统计学差异(尺0．05)；中药银屑组与雷公藤组比 较：银屑0，l，2，3号均具有统计学差异(P(O．05)。 结论： 中药银屑1号可能通过抑制中性粒细胞分泌的NE表达水平，以及抑制trappin一2 的表达水平，从而调节NE以及NE的抑制剂trappin-2，保持两者的平衡，从而达到 治疗作用。 关键词：银屑病；NE；Trappin一2；中性粒细胞；中药银屑1号 The effect of Trad it i ona I Ch i nese med i C i Re(TCM)Y i n X i e 1 hao on i n V i tro CU Itured neutroph i I s secreted NE、trapp i n一2 SpeciaIty：DermatoIogy，Chinese TraditionaI Surgery Author：Pingping huang Tutor：Associate Professor Jing LiU Abstract Objective Now mainly concentrated on the study of psoriasis in T cells，lymphocytes， although there are some people began to study the neutrophils，but a few．But as the latest study found that，in fact，those who have the neutrophilS invasion detected iS a lot of．It is considered one of the major effector celis are nonspecific inflazmmtion reaction，and carl affect the psoriatic condition of many of cytokines secreted by the neutrophils．Then，through the neutrophil elastase(neutrophiI elastase，NE)of in-depth study，through which we can gain a better understanding of the neutrophils．NE of the inhibitors for trappin 一2，they are the two with psoriasis was closely related to two factors．So someone put forward NE／trappin一2 is imbalance can cause psoriasi S． We are from the above，the contents of the associated with the traditional Chinese medicine treatment of psoriasis is effective，traditional Chinese medicine for treating psoriasiS iS also can affect the secretion of neutrophiIs NE and its balance with trappin一27Despite the above conjecture，but if no one is really study published in some magazines．So we throu曲the study of different concentration of traditionaI Chinese medicine compound l silver crumbs drug—containing serum on in vitro cultured neutrophils secreted NE， the influence of trappin一2，and，if can be trappin一2 in the hum