血清脂蛋白a、同型半胱氨酸和肱踝脉搏波传导速度与冠心病病变的关系分析.docVIP

血清脂蛋白a、同型半胱氨酸和肱踝脉搏波传导速度与冠心病病变的关系分析 　　[摘要] 目的 探讨血清脂蛋白a[Lp（a）]、同型半胱氨酸（Hcy）和肱踝脉搏波传导速度（baPWV）与冠心病病变血管的关系。 方法 选取2012年1月～2013年12月本院确诊的138例冠心病患者作为冠心病组，同时选取62例冠状动脉造影检查（CAG）正常者作为对照组，其中冠心病组又分为单支病变组54例，双支病变组51例，多支病变组33例。采用免疫比浊法测定Lp（a），荧光免疫分析法测定血清Hcy及动脉硬化检测仪检测baPWV。 结果 冠心病组的血清Lp（a）、HCY、baPWV水平显著高于非冠心病组，差异有统计学意义（P0.05）。多支病变组的Lp（a）、Hcy、baPWV水平高于单支及双支病变组，差异有统计学意义（P0.05）。双支病变组的Lp（a）、Hcy、baPWV水平高于单支病变组，差异有统计学意义（P0.05）。 结论 血清Lp（a）、Hcy、baPWV水平与冠心病病变血管的病变程度相关，三者结合起来可以用来辅助诊断冠心病及其病变血管的病变程度，从而为临床更有效地诊治冠心病提供可靠的依据。 　　[关键词] 冠心病；脂蛋白a；同型半胱氨酸；肱踝脉搏渡传导速度 　　[中图分类号] R541.4 [文献标识码] A [文章编号] 1674-4721（2015）07（b）-0034-04 　　[Abstract] Objective To explore the association of coronary heart disease （CHD） with plasma Lp（a），Hcy and brachial- ankle PWV （baPWV）. Methods 138 patients diagnosed CHD in our hospital from January 2012 to December 2013 were selected as the CHD group，62 cases of healthy subjects by CAG were selected as the control group，the CHD group further was divided into single-branch-affected （SBA） group （n=54），two-branch-affected （TBA） group （n=51） and multi-branch-affected （MBA） group （n=33）.The level of Plasma Lp（a） was measured by the immunoturbidimetry，the level of Hcy was measured by the fluorescence immunoassay and baPWV was measured using the detector of artery hardening. Results The level of Lp（a），Hcy and baPWV in the CHD group was higher than that in the non-CHD group，with significant difference（P0.05）.The level of Lp（a），Hcy and baPWV in the MBA group was higher than that in the SBA and the TBA group，with significant difference（P0.05）.The level of Lp（a），Hcy and baPWV in the TBA group was higher than that in the SBA group，with significant difference（P0.05）. Conclusion The level of Lp（a），Hcy and baPWV is correlated with the severity degree of CHD.The combination of three detection can be used to predict CHD and the hazard degree，which can provide reliable diagnosis for more effective prevention and treatment of CHD on clinic. 　　[Key words] Coronary heart disease；Lipoprotein （a）；Ho